Department of Dermatology
Professor
Kunihiko Tamaki, M.D., Ph.D.
Associate Professor
Kanako Kikuchi, M.D., Ph.D. Akihiko Asahina, M.D., Ph.D.
Lecturer
Mayumi Komine, M.D., Ph.D. Hironobu Ihn, M.D., Ph.D.
Hidehisa Saeki, M.D., Ph.D. Takahiro Watanabe, M.D., Ph.D.
Associate
Takafumi Kadono, M.D. Naoko Hattori, M.D.
Margit Nindl, M.D., Ph.D. Takashi Kakinuma, M.D.
Junichiro Shikada, M.D. Kennichi Yamane, M.D., Ph.D.
Akira Shirai, M.D. Takeo Maekawa, M.D.
Etsuko Kato, M.D.

Outline and Research, clinical, teaching activities
The Department of dermatology celebrated its 100th anniversary in 1990. Originally it was founded as the Department of dermatology and Urology, which also encompassed venereology. In 1946 the Department of dermatology was separated from that of Urology. Department of Dermatology had its branch department in Branch Hospital for about 50 years until these two departments joined in 2001. A professor, two associate professors, four lecturers and nine associates take part in inpatient and out-patient cares as well as research and teaching activities. We usually have around 10 residents and 8 students of doctoral PhD. Course. Thirty doctors who basically belong to our department are currently out in affiliated hospitals mainly engaged in clinical works there. Additionally there are four staff members abroad in the US and involved in advanced research activities in cell biology and molecular biology as postdoctoral fellow.
We have specialized out-patient clinic in which some of doctors who are in affiliated hospitals also participate and each specialized service reflects its own research field in a disease oriented manner.
O course these specialized groups performing their clinical and research activities are not exclusive, and there are increasing communications in our department as well as with other departments. Specialized out-patient clinic include the following: atopic dermatitis, psoriasis, collagen diseases including systemic sclerosis, SLE and dermatomyosites, skin surgery and laser surgery including malignant melanoma, squamous cell carcinoma and basal cell carcinoma, and infection especially fungal infection. These clinical groups are divided into three main research groups; 1) immunology and allergology gourp, 2) collagen disease group and 3) skin surgery group.
Immunology and allergology group engaged in atopic dermatitis and psoriasis clinic and focuses on Landerhans cell and keratinocyte biology research including cytokine and chemokine. Collagen group engaged in collagen disease clinic and focuses mechanisms relating TGF-? and collagen. Skin surgery group engaged in skin surgery and laser surgery clinic and focuses of tumor growth, metastasis, fibrosis and dermatoscopic clinical study. Research groups are maintained by associated professor or lecturer. These senior investigators have ten to fifteen year experience as dermatologist and more than seven-year experience of research in Japan as well as in USA. They have one to three associates and students of Ph.D. course to extend their research.

In the out-patient clinic we see around 200 patients a day. Incisional and excisional biopsies are frequently performed under local anesthesia at the outpatient operation facilities belonging to our department Daily discussions are made for initially consulted cases when they are rather difficult to diagnose, by all staff members including Professor and Associate Professors. Furthermore, retrospective clinical and histological discussions are held regularly, which always give us invaluable lessons.
Concerning the in-patient clinic, we usually have around 40 patients in the ward, which are usually taken care of by about ten staff members under the supervision of the ward-chief. Surgical operations such as removal of malignancies and skin grafting that require general anesthesia are also performed weekly in the central surgical facilities.
We have ten dermatologists who are studying in the postgraduate course under the guidance of staff members of our department.
In addition to series of lectures, clinical education is provided for fifth and sixth grade medical students, which aims at giving a general introduction for how to make dermatological approaches for diagnosis and treatment, with a stress on learning how to observe and describe a variety of skin eruptions. Actually the students are supposed to see the initially consulted, selected patients every day for an entire week, as well as to participate in the in-patient clinic.

References
  1. Kikuchi K, Kubo M, Hoashi T, Tamaki K: Decreased MMP-9 activity in the serum of patients with diffuse cutaneous systemic sclerosis. Clin Exp Dermatol 27: 310-315, 2002.
  2. Soma Y, Mizoguchi M, Yamane K, Yazawa N, Kubo M, Ihn H, Kikuchi K, Tamaki K: Specific inhibition of human skin fibroblast chemotaxis to platelet-derived growth factor A-chain homodimer by transforming growth factor-?1. Arch Dermatol Res 293: 609-613, 2002.
  3. Lew W, Chang SK, Kwahck H, Tada Y, Nakamura K, Tamaki K: Serum monocyte chemoattractant protein-1 is elevated in lepromatous leprosy patients with high bacterial indices. Int J Lepr Other Mycobact Dis 70: 129-131, 2002.
  4. Zheng X, Nakamura K, Tojo M, Oyama N, Nishibu A, Satoh M, Kakinuma T, Wakugawa M, Tamaki K, Kaneko F: TGF-beta (1)-mediated regulation of thymus and activation-regulated chemokine (TARC/CCL17) synthesis and secretion by HaCaT cells co-stimulated with TNF-alpha and IFN-gamma. J Dermatol Sci 30: 154-160, 2002.
  5. Komine M, Nishina H, Ohtsuki M, Nakagawa H, Tamaki K: Effects of vitamin D3 analogues on the immunomodulatory function of keratinocytes and lymphocytes. Tsambaos D, Merk H Eds: Modern Trends in Skin Pharmacology. Athens: Parissianos Medical Publications; p. 67-74, 2002.
  6. Seiffert K, Hosoi J, Torii H, Ozawa H, Ding W, Campton K, Wagner JA, Granstein RD: Catecholamines inhibit the antigen-presenting capability of epidermal Langerhans cells. J Immunol 168: 6128-6135, 2002.
  7. Ihn H: The role of TGF-? signaling in the pathogenesis of fibrosis in scleroderma. Arch Immunol Ther Exp 50: 325-331, 2002.
  8. Ihn H: Pathogenesis of fibrosis: role of TGF-? and CTGF. Curr Opin Rheumatol 14: 681-685, 2002.
  9. Ihn H, Yamane K, Asano Y, Kubo M, Tamaki K: Interleukin-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase-dependent pathway. J Immunol 168: 1895-1902, 2002.
  10. Ihn H, Tamaki K: Mitogenic activity of dermatofibrosarcoma protuberans is mediated via an extracellular signal related kinase dependent pathway. J Invest Dermatol 119: 954-960, 2002.
  11. Ihn H, Asano Y, Kubo M, Yamane K, Jinnin M, Yazawa N, Fujimoto M, Tamaki K: Clinical significance of serum surfactant protein D (SP-D) in patients with polymyositis/dermatomyositis: correlation with interstitial lung disease. Rheumatology 41: 1268-1272, 2002.
  12. Saeki H, Hattori N, Mitsui H, Adachi M, Imakado S, Ishibashi Y, Tamaki K: A keratin 10 gene mutation (Arg156Cys) in a Japanese patient with bullous congenital ichthyosiform erythroderna. J Dermatol 29: 168-171, 2002.
  13. Saeki H, Asano N, Tsunemi Y, Takekoshi T, Kishimoto M, Mitsui H, Tada Y, Torii H, Komine M, Asahina A, Tamaki K: Polymorphisms of vitamin D receptor gene in Japanese patients with psoriasis vulgaris. J Dermatol Sci 30: 167-171, 2002.
  14. Watanabe T, Kawamura T, Jacob SE, Aquilino EA, Orenstein JM, Black JB, Blauvelt A: Pityriasis rosea is associated with systemic active infection with both human herpesvirus-7 and human herpesvirus-6. J Invest Dermatol 119: 793-797, 2002.
  15. Wakugawa M, Nakamura K, Kakinuma T, Tamaki K: CC chemokine receptor 4 as a possible target for therapy of atopic dermatitis. Drug News Perspect 15: 175-179, 2002.
  16. Kadono T, Inaoka T, Murayama N, Ushijima K, Nagano M, Nakamura S, Watanabe C, Tamaki K, Ohtsuka R: Skin manifestations of arsenicosis in two villages of Bangladesh. Int J Dermatol 41: 841-846, 2002.
  17. Kadono T, Venturi GM, Steeber DA, Tedder TF: Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. J Immunol 169: 4542-4550, 2002.
  18. Hamaguchi Y, Nishizawa Y, Yasui M, Hasegawa M, Kaburagi Y, Komura K, Nagaoka T, Saito E, Shimada Y, Takehara K, Kadono T, Steeber DA, Tedder TF, Sato S: Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. Am J Pathol 161: 1607-1618, 2002.
  19. Kaburagi Y, Hasegawa M, Nagaoka T, Shimada Y, Hamaguchi Y, Komura K, Saito E, Yanaba K, Takehara K, Kadono T, Steeber DA, Tedder TF, Sato S: The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. J Immunol 168: 2970-2978, 2002.
  20. Tu L, Poe JC, Kadono T, Venturi GM, Bullard DC, Tedder TF, Steeber DA: A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol 169: 2034-2043, 2002.
  21. Hattori N, Komine M, Yano S, Kaneko T, Hanakawa Y, Hashimoto K, Tamaki K: Interferon-?, a strong suppressor of cell proliferation, induces upregulation of keratin 6, one of the inflammatory- and proliferation-associated keratins. J Invest Dermatol 119: 403-410, 2002.
  22. Fujimoto M, Poe JC, Satterthwaite AB, Wahl MI, Witte ON, Tedder TF: Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction. J Immunol 168: 5465-5476, 2002.
  23. Kubo M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: Prevalence of 52-kDa and 60-kDa Ro/SS-A autoantibodies in Japanese patients with polymyositis/dermatomyositis. J Am Acad Dermatol 47: 148-151, 2002.
  24. Kubo M, Ihn H, Yamane K, Tamaki K: Up-regulated expression of transforming growth factor ? receptors in dermal fibroblasts of the skin sections from patients with systemic sclerosis. J Rheumatol 29: 2558-2564, 2002.
  25. Kubo M, Ihn H, Kuwana M, Asano Y, Tamaki T, Yamane K, Tamaki K: Anti-U5 snRNP antibody as a possible serological marker for scleroderma-polymyositis overlap. Rheumatology 41: 531-534, 2002.
  26. Nagaoka Y, Asahina A, Yano S, Tamaki K: Bilateral segmental neurofibromatosis. Acta Derm Venereol 82: 219-220, 2002.
  27. Nagaoka Y, Nakamura K, Yasaka N, Watanabe T, Asahina A, Tamaki K: Identification and characterization of the low-affinity receptor for immunoglobulin E (FcepsilonRII/CD23) on murine Langerhans cells. J Invest Dermatol 119: 130-136, 2002.
  28. Kakinuma T, Nakamura K, Wakugawa M, Mitsui H, Tada Y, Saeki H, Torii H, Komine M, Asahina A, Tamaki K: Serum macrophage-derived chemokine (MDC) levels are closely related with the disease activity of atopic dermatitis. Clin Exp Immunol 127: 270-273, 2002.
  29. Kakinuma T, Nakamura K, Wakugawa M, Yano S, Saeki H, Torii H, Komine M, Asahina A, Tamaki K: IL-4, but not IL-13, modulates TARC (thymus and activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein of 10kDa)/CXCL10 release by TNF? and IFN? in HaCaT cell line. Cytokine 20: 1-6, 2002.
  30. Sugaya M, Nakamura K, Watanabe T, Asahina A, Yasaka N, Koyama Y, Kusubata M, Ushiki Y, Kimura K, Morooka A, Irie S, Yokoyama T, Inoue K, Itohara S, Tamaki K: Expression of cellular prion-related protein by murine Langerhans cells and keratinocytes. J Dermatol Sci 28: 126-134, 2002.
  31. Yano S, Nakamura K, Okochi H, Tamaki K: Analysis of the expression of cutaneous lymphocyte-associated antigen on the peripheral blood and cutaneous lymphocytes of alopecia areata patients. Acta Derm Venereol 82: 82-85, 2002.
  32. Ito Y, Arai S, van Oers NS, Aifantis I, von Boehmer H, Miyazaki T: Positive selection by the pre-TCR yields mature CD8+ T cells. J Immunol 169: 4913-4919, 2002.
  33. Mitsui H, Komine M, Watanabe T, Kikuchi K, Okochi H, Tamaki K: Does Hermansky-Pudlak syndrome predispose to systemic lupus erythematosus? Br J Dermatol 146: 908-911, 2002.
  34. Yamane K, Ihn H, Kubo M, Tamaki K: Increased transcriptional activities of transforming growth factor-? receptors in scleroderma fibroblasts. Arthritis Rheum 46: 2421-2428, 2002.
  35. Jinnin M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: A case of linear scleroderma with muscle calcification. Br J Dermatol 146: 1084-1086, 2002.
  36. Jinnin M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: Autoimmune response to 52-kDa and 60-kDa Ro/SS-A antigens in mixed connective tissue disease. Br J Dermatol 147: 827-829, 2002.
  37. Jinnin M, Ihn H, Yamane K, Asano Y, Yazawa N, Tamaki K: Serum levels of tissue inhibitor of metalloproteinases in patients with mixed connective tissue disease. Clin Exp Rheumatol 20: 539-542, 2002.
  38. Tsunemi Y, Hattori N, Saeki H, Adachi M, Komine M, Nakagawa H, Tamaki K: A keratin 9 gene mutation (Asn160Ser) in a Japanese patient with epidermolytic palmoplantar keratoderma. J Dermatol 29: 768-772, 2002.
  39. Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Fujita H, Asano N, Kishimoto M, Tanida Y, Kakinuma T, Mitsui H, Tada Y, Wakugawa M, Torii H, Komine M, Asahina A, Tamaki K: Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris. J Dermatol Sci 30: 161-166, 2002.
  40. Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Kakinuma T, Fujita H, Asano N, Tanida Y, Wakugawa M, Torii H, Tamaki K: Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients. J Dermatol Sci 30: 100-107, 2002.
  41. Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Fujita H, Asano N, Tanida Y, Kakinuma T, Wakugawa M, Torii H, Tamaki K: Eotaxin gene single nucleotide polymorphisms in the promoter and exon regions are not associated with susceptibility to atopic dermatitis, but two of them in the promoter region are associated with serum IgE levels in patients with atopic dermatitis. J Dermatol Sci 29: 222-228, 2002.
  42. Ohtsuki M, Nakagawa H, Sugai J, Ozawa A, Ohkido M, Nakayama J, Hanada J, Morimoto Y, Jimbow K, Horikoshi T, Kitahara H, Tamaki K, Urabe K, Hori Y: Long-term continuous versus intermittent cyclosporin: therapy for psoriasis. J Dermatol 30: 290-298, 2003.
  43. Takahashi T, Nakamura K, Chiba S, Kanda Y, Tamaki K, Hirai H: V alpha 24+ natural killer T cells are markedly decreased in atopic dermatitis patients. Hum Immunol 64: 586-592, 2003.
  44. Adachi M, Gazel A, Pintucci G, Shuck A, Shifteh S, Ginsburg D, Rao LS, Kaneko T, Freedberg IM, Tamaki K, Blumenberg M: Specificity in stress response: epidermal keratinocytes exhibit specialized UV-responsive signal transduction pathways. DNA Cell Biol 22: 665-677, 2003.
  45. Kuwana M, Sato S, Kikuchi K, Kawaguchi Y, Fujisaku A, Misaki Y, Hatamochi A, Kondo H, Takehara K: Evaluation of functional disability using the health assessment questionnaire in Japanese patients with systemic sclerosis. J Rheumatol 30:1253-8,2003.
  46. Yasuoka H, Ihn H, Medsger TA Jr., Hirakata M, Kawakami Y, Ikeda Y, Kuwana M: A novel peotein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies. J Immunol 171: 6883-6890, 2003.
  47. Saeki H, Ohmatsu H, Hoashi T, Asano N, Idezuki T, Kawabata Y, Asahina A, Kikuchi K, Tamaki K: Dermatofibrosarcoma protuberans with COL1A1 (exon 18) - PDGFB (exon 2) fusion transcript. Br J Dermatol 148: 1028-1031, 2003.
  48. Saeki H, Hoashi T, Tada Y, Ashida R, Kuwano Y, Le Pavoux A, Shikada J, Torii H, Kawabata Y, Kikuchi K, Tamada Y, Matsumoto Y, Tamaki K: Analysis of gene mutations in three cases of dermatofibrosarcoma protuberans (DFSP): ordinary DFSP, DFSP with fibrosarcomatous lesion (DFSP-FS) and lung metastasis of DFSP-FS. J Dermatol Sci 33: 161-167, 2003.
  49. Sekiya T, Tsunemi Y, Miyamasu M, Ohta K, Morita A, Saeki H, Matsushima K, Yoshie O, Tsuchiya N, Yamaguchi M, Yamamoto K, Tamaki K, Hirai K: Variations in the human Th2-specific chemokine TARC gene. Immunogenetics 54: 742-745, 2003.
  50. Zheng X, Nakamura K, Tojo M, Akiba H, Oyama N, Nishibu A, Kaneko F, Tsunemi Y, Kakinuma T, Saeki H, Tamaki K: Ultraviolet A irradiation inhibits thymus and activation-regulated chemokine (TARC/CCL17) production by a human keratinocyte HaCaT cell line. Eur J Dermatol 13: 348-353, 2003.
  51. Watanabe T, Sugaya M, Atkins AM, Aquilino EA, Yang A, Borris DL, Brady J, Blauvelt A: Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen prolongs the life span of primary human umbilical vein endothelial cells. J Virol 77: 6188-6196, 2003.
  52. Venturi GM, Tu L, Kadono T, Khan AI, Fujimoto Y, Oshel P, Bock CB, Miller AS, Albrecht RM, Kubes P, Steeber DA, Tedder TF: Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity 19: 713-724, 2003.
  53. Hattori N, Kaneko T, Tamaki K, Makimura K, Mochizuki T: A case of kerion celsi due to Arthroderma benhamiae identified by DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions. Med Mycol 41: 249-251, 2003.
  54. Sato S, Hayakawa I, Hasegawa M, Fujimoto M, Takehara K: Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis. J Invest Dermatol 120: 542-547, 2003.
  55. Yanaba K, Hasegawa M, Hamaguchi Y, Fujimoto M, Takehara K, Sato S: Longitudinal analysis of serum KL-6 levels in patients with systemic sclerosis: association with the activity of pulmonary fibrosis. Clin Exp Rheumatol 21: 429-436, 2003.
  56. Hasegawa M, Sato S, Nagaoka T, Fujimoto M, Takehara K: Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma. Dermatology 207: 141-147, 2003.
  57. Furuse S, Fujii H, Kaburagi Y, Fujimoto M, Hasegawa M, Takehara K, Sato S: Serum concentrations of the CXC chemokines interleukin 8 and growth-regulated oncogene-alpha are elevated in patients with systemic sclerosis. J Rheumatol 30: 1524-1528, 2003.
  58. Sato S, Fujimoto M, Hasegawa M, Takehara K: Antiphospholipid antibody in localised scleroderma. Ann Rheum Dis 62: 771-774, 2003.
  59. Kubo M, Czuwara-Ladykowska J, Moussa O, Markiewicz M, Smith E, Silver RM, Jablonska S, Blaszczyk M, Watson DK, Trojanowska M: Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol 163: 571-581, 2003.
  60. Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, Tada Y, Wakugawa M, Watanabe T, Torii H, Komine M, Asahina A, Nakamura K, Tamaki K: Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris. J Allergy Clin Immunol 111: 592-597, 2003.
  61. Kakinuma T, Wakugawa M, Nakamura K, Hino H, Matsushima K, Tamaki K: High level of thymus and activation-regulated chemokine in blister fluid and sera of pat ients with bullous pemphigoid. Br J Dermatol 148: 203-10, 2003.
  62. Kakinuma T, Sugaya M, Nakamura K, Kaneko F, Wakugawa M, Matsushima K, Tamaki K: Thymus and activation-regulated chemokine (TARC/CCL17) in mycosis fungoides: serum TARC levels reflect the disease activity of mycosis fungoides. J Am Acad Dermatol 48: 23-30, 2003.
  63. Zheng X, Nakamura K, Furukawa H, Nishibu A, Takahashi M, Tojo M, Kaneko F, Kakinuma T, Tamaki K: Demonstration of TARC and CCR4 mRNA expression and distribution using in situ RT-PCR in the lesional skin of atopic dermatitis. J Dermatol 30: 26-32, 2003.
  64. Yazawa N, Fujimoto M, Sato S, Miyake K, Asano N, Nagai Y, Takeuchi O, Takeda K, Okochi H, Akira S, Tedder TF, Tamaki K: CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. Blood 102:1374-1380, 2003.
  65. Nagaoka Y, Okochi H, Tamaki K: Leukocytopenia after administration of itraconazole. Mycoses 46: 240-241, 2003.
  66. Sugaya M, Nakamura K, Mitsui H, Takekoshi T, Saeki H, Tamaki K: Human keratinocytes express fractalkine / CX3CL1. J Dermatol Sci 31: 179-187, 2003.
  67. Kawamura T, Gulden FO, Sugaya M, McNamara DT, Borris DL, Lederman MM,Orenstein JM, Zimmerman PA, Blauvelt: R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms. Proc Natl Acad Sci USA 100: 8401-8406, 2003.
  68. Tada Y, Asahina A, Fujita H, Sugaya M, Tamaki K: Langerhans cells do not produce interferon-gamma. J Invest Dermatol 120: 891-892, 2003.
  69. Yano S, Komine M, Fujimoto M, Okochi H, Tamaki K: Interleukin 15 induces the signals of epidermal proliferation through ERK and PI 3-kinase in a human epidermal keratinocyte cell line, HaCaT. Biochem Biophys Res Commun 301: 841-847, 2003.
  70. Mitsui H, Komine M, Shirai A, Kanda N, Asahina A, Okochi H, Hitomi S, Kimura S, Tamaki K: Chronic active EB virus infection complicated with IgG3 subclass deficiency: an adult case treated with intravenous immunoglobulin and IFN-alpha. Acta Derm Venereol 83: 31-35, 2003.
  71. Wakimoto K, Chiba H, Michibata H, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y: A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice. Biochem Biophys Res Commun 310: 296-302, 2003.
  72. Yamane K, Ihn H, Tamaki K: Epidermal growth factor up-regulates expression of transforming growth factor-??receptor type II in human dermal fibroblasts by phosphoinositide 3-kinase/ Akt signaling pathway: Resistance to epidermal growth factor stimulation in scleroderma fibroblasts. Arthritis Rheum 48: 1652-1666, 2003.
  73. Yamane K, Ihn H, Asano Y, Jinnin M, Tamaki K: Antagonistic effects of TNF-? on TGF-? signaling through downergulation of TGF? receptor type II in human dermal fibroblasts. J Immunol 171: 3855-3862, 2003.
  74. Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K: The prevalence and clinical significance of anti-U1RNA antibodies in patients with systemic sclerosis. J Invest Dermatol 120: 204-210, 2003.
  75. Jinnin M, Ihn H, Yazawa N, Asano Y, Yamane K, Tamaki K: Circulating soluble CD40 ligand in patients with eosinophilic faciitis. Ann Rheum Dis 62: 190-191, 2003.
  76. Jinnin M, Ihn H, Yamane K, Asano Y, Yazawa N, Tamaki K: Plasma plasmin-?2 plasmin inhibitor complex levels are increased in systemic sclerosis with pulmonary hypertension. Rheumatology 42: 240-243, 2003.
  77. Jinnin M, Ihn H, Yamane K, Asano Y, Yazawa N, Tamaki K: Clinical features of patients with systemic sclerosis accompanied by rheumatoid arthritis. Clin Exp Rheumatol 21: 91-94, 2003.
  78. Jinnin M, Ihn H, Yazawa N, Asano Y, Yamane K, Tamaki K: Elevated circulating soluble CD40 ligand in patients with mixed connective tissue disease. Clin Rheumatol 22: 37-39, 2003.
  79. Jinnin M Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: Effect of D-penicillamine on pulmonary fibrosis in patients with systemic sclerosis. Ann Rheum Dis 62: 1019-1020, 2003.
  80. Jinnin M, Ihn H, Yazawa N, Asano Y, Yamane K, Tamaki K: Elevated serum levels of manganese superoxide dismutase in patients with eosinophilic fasciitis. Clin Rheumatol 22: 505, 2003.
  81. Tsunemi Y, Matsushita T, Takahashi T, Tamaki T: Childhood capillary hemangioma presenting as infantile perianal protrusion. Dermatology 207: 408-409, 2003.
  82. Tsunemi Y, Nishibu A, Saeki H, Oyama N, Nakamura K, Kishimoto M, Mitsui H, Tada Y, Torii H, Komine M, Asahina A, Kaneko F, Tamaki K: Lack of association between the promoter polymorphisms at positions -308 and -238 of the tumor necrosis factor alpha gene and psoriasis vulgaris in Japanese patients. Dermatology 207: 371-374, 2003.
  83. Tsunemi Y, Sekiya T, Saeki H, Hirai K, Ohta K, Nakamura K, Kakinuma T, Fujita H, Asano N, Wakugawa M, Torii H, Tamaki K: Lack of association of CCR3 single nucleotide polymorphism with atopic dermatitis in Japanese population. J Dermatol Sci 33: 130-133, 2003.
  84. Tsunemi Y, Idezuki T, Nakamura K, Tamaki K: Dermal endothelial cells express eotaxin in hypereosinophilic syndrome. J Am Acad Dermatol 49: 918-921, 2003.
  85. Tsunemi Y, Ihn H, Shimada Y, Takehara K, Manabe M, Tamaki K: Rosai-Dorfan disease presenting as large pigmented indurated plaques. Acta Derm Venereol 83: 57-58, 2003.
  86. Tsunemi Y, Ihn H, Idezuki T, Okochi H, Tamaki K: Psoriasis guttata in association with hepatocellular carcinoma. Acta Derm Venereol 83: 70-71, 2003.
  87. Tsunemi T, Ihn H, Nakamura K, Tamaki K: Post-transplantation chronic graft-versus-host disease with overlapping features similar to those of various collagen diseases. Int J Dermatol 42: 292-294, 2003.
  88. Tsunemi Y, Ihn H, Hattori N, Saeki H, Tamaki K: Multiple eruptive dermatofibromas with CD34+ cells in a patient with hyperglyceridemia. Dermatology 207: 319-321, 2003.
  89. Tsunemi Y, Ihn H, Saeki H, Tamaki K: Cholinergic urticaria successfully treated with scopolamine butylbromide. Int J Dermatol 42: 850, 2003.
  90. Tsunemi Y, Ihn H, Saeki H, Tamaki K: Epithelioid granulomas in post-transplantation chronic graft-versus-host disease. Br J Dermatol 149: 898-899, 2003.
  91. Tsunemi Y, Takahashi T, Tamaki T: Penicillium marneffei infection diagnosed by polymerase chain reaction from the skin specimen. J Am Acad Dermatol 49: 344-346, 2003.
  92. Tsunemi Y, Saeki H, Kishimoto M, Mitsui H, Tada Y, Torii H, Komine M, Asahina A, Tamaki K, Sekiya T: Cytotoxic T lymphocyte antigen-4 gene (CTLA4) polymorphisms in Japanese patients with psoriasis vulgaris. J Dermatol Sci 32:163-165, 2003.
  93. Ohno Y, Le Pavouv A, Saeki H, Asahina A, Tamaki K: A case of subcutaneous nodular fat necrosis with lipase-secreting acinar cell carcinoma. Int J Dermatol 42: 384-385, 2003.
  94. Kagami S, Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Nakamura K, Takekoshi T, Kishimoto M, Mitsui H, Torii H, Komine M, Asahina A, Tamaki K: Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: serum eotaxin-3/CCL26 levels reflect the disease activity of atopic dermatitis. Clin Exp Immunol 134: 309-313, 2003.
  95. Xiao T, Kagami S, Saeki H, Sugaya M, Kakinuma T, Fujita H, Yano S, Mitsui H, Torii H, Komine M, Asahina A, Nakamura K, Tamaki K: Both IL-4 and IL-13 inhibit the TNF-??and IFN-? enhanced MDC production in a human keratinocyte cell line, HaCaT cells. J Dermatol Sci 31: 111-117, 2003.
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Annual Report of the Graduate School of Medicine and The Faculty of Medicine The University of Tokyo Reports for the Period April 2002 - March 2004