Department of Gastroenterology
Professor Masao
Omata, M.D., Ph.D.

Lecturer
Haruhiko Yoshida, M.D., Ph.D.
Shuichiro Shiina, M.D., Ph.D.

Associate　
Hiroshi Kanamori, M.D., Ph.D. Minoru Tada, M.D., Ph.D.
Tomoaki Tomiya, M.D., Ph.D. Hiroshi Mitsui, M.D., Ph.D.
Naoya Kato, M.D., Ph.D. Yutaka Komatsu, M.D., Ph.D.
Hirosato Mashima, M.D., Ph.D. Naohisa Yahagi, M.D., Ph.D.
Makoto Okamoto, M.D., Ph.D. Keiji Ogura, M.D., Ph.D.
Takuma Teratani, M.D., Ph.D.  Yutaka Yamaji, M.D., Ph.D.
Mikio Yanase, M.D., Ph.D. Hajime Fujie, M.D., Ph.D.
Hiroyuki Isayama, M.D., Ph.D.

Organization
The Department of Gastroenterology was established through the reorganization of the Postgraduate School of Medicine and that of the Division of Internal Medicine of the University of Tokyo Hospital. Gastroenterologists, formerly belonged to the First, Second, Third or Fourth Department of Internal Medicine or the Department of Physical Therapy and Medicine, joined the new department, which is now constituted of a professor, two lecturers, fifteen associates, eleven fellows, more than thirty graduates including five students from abroad, and several other visiting members. The department is responsible for both medical practice and education on gastroenterology.

Clinical Activities
The Department of Gastroenterology is in charge of about seventy to eighty inpatients on average. A resident, a junior and a senior staff members bear the responsibility for the medical management of each inpatient, in collaboration with concerned subspecialty groups. In addition, the staff members examine about 4,400 outpatients with various digestive diseases in a month.
The most frequent cause of admission is hepatocellular carcinoma (600 patients a year). 80% of patients with hepatocellular carcinoma receive medical treatment, such as percutaneous ethanol infection therapy and percutaneous radiofrequency ablation. About 50 patients a year are treated for choledocholithiasis with endoscopic papillary balloon dilation method. Internal metallic stent is preferred to percutaneous external drainage in the palliative care of malignant obstructive jaundice (40 patients a year). Endoscopic treatments such as endoscopic mucosal resection of neoplasm in the stomach or colon (150 patients a year) and endoscopic variceal ligation for esophageal varices (50 patients a year) are also frequently done. All those interventions are performed by members of the department especially trained in each technique.

Educational Activities
Systematic and clinical lectures on gastroenterology are regularly given to undergraduate medical students by staff members of the department. In addition, several courses of practical teaching are provided for the students. In particular, the Department of Gastroenterology makes much of the importance of bed-side teaching for the fifth and sixth grade students, where each student is allotted an inpatient and join the group of physicians in charge of the patient in medical examination and treatment. The results are to be reported to the professor at the end of the course. Students are also requested to be present at the weekly round by the professor, various gastroenterological examinations and treatments, and educational lectures on gastroenterology given by staff members. They also read and summarize gastroenterological articles on top-notch medical journals.
Residents of internal medicine join the Department of Gastroenterology for three months in rotation in their first year as a doctor, where they learn therapeutics and diagnostics in gastroenterology together with general medicine. If they are interested in gastroenterology in particular, they may learn advanced techniques in gastroenterology in affiliated hospitals for a few years. Usually, they will come back to the department after that period and improve their clinical skills still further while educating residents. The majority of them also start medical researches, basic or clinical, as a graduate student.

Research Activities
Since gastroenterology covers various organs, everything below the diaphragms except for the kidneys and the reproductive system, and protean diseases, such as neoplasm, infection, metabolic disorders and mechanical ones, themes of research are virtually unlimited, as shown in the list of publication described below. Basic and clinical researches are equally encouraged, on condition that the results may eventually benefit the cure of patients with gastroenterological disorders. In basic researches, the department has been eager to acquire cutting-edge methodologies, especially those in molecular biology and genetics. In clinical researches, objective studies are highly appreciated and several randomized-controlled studies are underway.

References
  1. Aizaki H, Harada T, Otsuka M, Seki N, Matsuda M, Li YW, Kawakami H, Matsuura Y, Miyamura T, Suzuki T. Expression profiling of liver cell lines expressing entire or parts of hepatitis C virus open reading frame. Hepatology 2002; 36(6) : 1431-1438.
  2. Akanuma M, Maeda S, Ogura K, Mitsuno Y, Hirata Y, Ikenoue T, Otsuka M, Watanabe T, Yamaji Y, Yoshida H, Kawabe T, Shiratori Y, Omata M. The evaluation of putative virulence factors of Helicobacter pylori for gastroduodenal disease by use of a short-term Mongolian gerbil infection model. J Infect Dis 2002 ; 185 : 341-347.
  3. Akanuma M, Yoshida H, Okamoto M, Ogura K, Maeda S, Hata Y, Sato S, Shiina S, Kawabe T, Shiratori Y, Omata M. Risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma. Hepato Gastroenterology 2002 ; 49 : 1039-1044.
  4. Azuma T, Takei M, Yoshikawa T, Nagasugi Y, Kato M, Otsuka M, Shiraiwa H, Sugano S, Mitamura K, Sawada S, Masuho Y, Seki N. Identification of candidate genes for Sjogren's syndrome using MRL/lpr mouse model of Sjogren's syndrome and cDNA microarray analysis. Immunol Lett 2002 ; 81(3) : 171-176.
  5. Brunet A, Kanai F (Co-first authors), Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB. 14-3-3 Transits to the Nucleus and Participates in Dynamic Nucleo-Cytoplasmic Transport. J Cell Biol 2002 ; 156 : 817-828.
  6. Fujishiro M, Yahagi N, Oka M, Enomoto S, Yamamichi N, Kakushima N, Tateishi A, Wada T, Shimizu Y, Ichinose M, Kawabe T, Omata M.　Endoscopic spraying of sucralfate using the outer sheath of a clipping device. Endoscopy 2002 ; 34 : 935.
  7. Fujishiro M, Kamoshida T, Hotra S, Hirai S, Oka Y, Sato M, Okumura M, Inadome Y, Takahashi A. Retroperitoneal lymphangioma with a duodenal lesion in an adult. J Gastroenterol 2002 ; 37(5) : 381-386.
  8. Fujiwara K, Yokosuka O, Ehata T, Saisho H, Saotome N, Suzuki K, Okita K, Kiyosawa K, Omata M. Association between severity of type A hepatitis and nucleotide variations in the 5' non-translated region of hepatitis A virus RNA: strains from fulminant hepatitis have fewer nucleotide substitutions. Gut 2002 ; 51 : 82-88.
  9. Gunji T, Kawaguchi N, Akahane M, Watanabe K, Kanamori K, Ohnishi S. Long-term outcomes of transcatheter arterial chemoembolization with autologoues blood clot for unresectable hepatocellular carcinoma. Int J Oncol 2002 ; 21: 427-432.
  10. Hirabayashi S, Ohno H, Iida J, Hata Y. C2PA is A nuclear protein implicated in the heat shock response. J Cell Biochem 2002 ; 87 : 65-74.
  11. Hirata Y, Maeda S, Mitsuno Y, Tateishi K, Yanai A, Akanuma M, Yoshida H, Kawabe T, Shiratori Y, Omata M. Helicobacter pylori CagA protein activates serum response element-driven transcription independently of tyrosine phosphorylation. Gastroenterology 2002 ; 123 : 1962-1971.
  12. Hoshida Y, Moriyama M, Otsuka M, Kato N, Goto T, Taniguchi H, Shiratori Y, Seki N, Omata M. Identification of genes associated with sensitivity to 5-fluorouracil and cisplatin in hepatoma cells. J Gastroenterol 2002 ; 37(Suppl) : S92-S95.
  13. Hoshida Y, Shiratori Y, Koike Y, Obi S, Hamamura K, Teratani T, Shiina S, Omata M. Hepatic volumetry to predict adverse events in percutaneous ablation of hepatocellular carcinoma. Hepato Gastroenterol 2002 ; 49 : 451-455.
  14. Hoshida Y, Shiratori Y, Omata M. Cost-effectiveness of adjuvant interferon therapy after surgical resection of Hepatitis C-related hepatocellular carcinoma. Liver 2002 ; 22 : 479-485.
  15. Ijichi M, Takayama T, Matsumura M, Shiratori Y, Omata M, Makuuchi M. alpha-Fetoprotein mRNA in the circulation as a predictor of postsurgical recurrence of hepatocellular carcinoma: a prospective study. Hepatology 2002 ; 35 : 853-860.
  16. Ikenoue T, Ijichi H, Kato N, Kanai F, Masaki T, Rengifo W, Okamoto M, Matsumura M, Kawabe T, Shiratori Y, Omata M.　Analysis of the beta-Catenin / T Cell Factor Signaling Pathway in 36 Gastrointestinal and Liver Cancer Cells. 　Jpn J Cancer Res 2002 ; 93 : 1213-1220.
  17. Inoue Y, Akahane M, Kitazawa T, Ijichi H, Obi S, Yoshikawa K, Ohtomo K, Omata M. False positive uptake of metaiodobenzylguanidine in hepatocellular carcinoma. Brit J Radiol 2002 ; 75 : 548-551.
  18. Inoue Y, Tomiya T, Yanase M, Arai M, Ikeda H, Tejima K, Ogata I, Kimura S, Omata M, Fujiwara K. p53 may positively regulate hepatocyte proliferation in rats. Hepatology 2002 ; 36 : 336-344.
  19. Isayama H, Komatsu Y, Tsujino T, Yoshida H, Tada M, Shiratori Y, Kawabe T, Omata M. Polyurethane-covered metal stent for management of distal malignant biliary obstruction. Gastrointest Endosc 2002 ; 55 : 366-370.
  20. Ishikawa T, Kohno T, Teratani T, Omata M. Thoracoscopic radiofrequency ablation therapy for hepatocellular carcinoma above the diaphragm associated with intractable hemothorax. Endoscopy 2002 ; 34 : 843.
  21. Kanamaru C, Yasuda H, Fujita T. Involvement of Smad proteins in TGF-b and activin A induced apoptosis and growth inhibition of liver cells. Hepatol Res 2002 ; 23 : 211-219.
  22. Katagiri H, Asano T, Yamada T, Aoyama T, Fukushima Y, Kikuchi M, Kodama T, Oka Y. Acyl-coenzyme A dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif. Mol Endocrinol 2002; 16 : 1049-1059.
  23. Kato J, Kato N, Moriyama M, Goto T, Taniguchi H, Shiratori Y, Omata M. Interferons Specifically Suppress the Translation from the Internal Ribosome Entry Site of Hepatitis C Virus through a Double-Stranded RNA-Activated Protein Kinase-Independent Pathway. J Infect Dis 2002 ; 186: 155-163.
  24. Kato J, Kato N, Yoshida H, Ono-Nita SK, Shiratori Y, Omata M. Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo. J Med Virol 2002 ; 66 : 187-199.
  25. Koike C, Mizutani T, Ito T, Shimizu Y, Yamamichi N, Kameda T, Michimukai E, Kitamura N, Okamoto T, Iba H. Introduction of wild-type patched gene suppresses the oncogenic potential of human squamous cell carcinoma cell lines including A431. Oncogene 2002 ; 21(17) : 2670-2678.
  26. Kubo M, Sasako M, Gotoda T, Ono H, Fujishiro M, Saito D, Sano T, Katai H. Endoscopic evaluation of the remnant stomach after gastrectomy: proposal for a new classification. Gastric Cancer 2002 ; 5(2) : 83-89.
  27. Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD. HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis. Oncogene 2002 ; 21 : 4801-4811.
  28. Maeda S, Anarsanaa J, Mitsuno Y, Hirata Y, Akanuma M, Ikenoue T, Ogura K, Yoshida H, Shiratori Y, Omata M. Relationship between nuclear factor-κB activation and virulence factors of Helicobacter pylori in Japanese clinical isolates. J Gastroenterol Hepatol 2002 ; 17 : 556-562.
  29. Maeda S, Yoshida H, Mitsuno Y, Hirata Y, Ogura K, Shiratori Y, Omata M. Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori. Gut 2002 ; 50 : 771-778.
  30. Maeda S, Yoshida H, Mitsuno Y, Hirata Y, Ogura K, Shiratori Y, Omata M. Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori. Mol Pathol 2002 ; 55 : 286-293.
  31. Matsuhashi N, Nakajima A, Wada K, Miki H, Saubermann L, Kubota N, Terauchi Y, Kadowaki T, Nagai R, Blumberg RS. Protective effects of PPAR? in gastrointestinal mucosal injuries. Recent Res Dev Immunol 2002 ; 4 : 227-233.
  32. Matsui A, Yanase M, Tomiya T, Ikeda H, Fuijiwara K, Ogata I. Stabilization of RNA strands in protein synthesis by type I procollagen C-proteinase enhancer protein, a potential RNA-binding protein, in hepatic stellate cells. Biochem Biophys Res Commun 2002 ; 290 : 898-902.
  33. Mitsuno Y, Maeda S, Yoshida H, Hirata Y, Ogura K, Akanuma M, Kawabe T, Shiratori Y, Omata M. Helicobacter pylori activates the proto-oncogene c-fos through SRE transactivation. Biochem Biophys Res Commun 2002 ; 291 : 868-874.
  34. Mizutani T, Ito T, Nishina M, Yamamichi N, Watanabe A, Iba H. Maintenance of Integrated Proviral Gene Expression Requires Brm, a Catalytic Subunit of SWI/SNF Complex. J Biol Chem 2002 ; 277(18) : 15859-15864.
  35. Nagata T, Matsumoto A, Uehara Y, Tanaka G, Oonuma H, Hara K, Igarashi K, Hazama H, Hirata Y, Shiratori Y, Omata M. Oxygenation abnormalities in normoxemic patients with mild liver cirrhosis. Internal Med 2002 ; 41 : 435-440.
  36. Nakano T, Inoue K, Hirohara J, Arita S, Higuchi K, Omata M, Toda G. Long-term prognosis of primary biliary cirrhosis (PBC) in Japan and analysis of the factors of stage progression in asymptomatic PBC (a-PBC). Hepatol Res 2002 ; 22 : 250-260.
  37. O'Neil T, Giarratani L, Chen P, Iyer L, Lee C-H, Bobiak M, Kanai F, Zhou B-B, Chung JH, Rathbun GA. Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the orientated peptide library approach. J Biol Chem 2002 ; 277 : 16102-16115.
  38. Ogihara T, Asano T, Ando K, Chiba Y, Sakoda H, Anai M, Shojima N, Ono H, Onishi Y, Fujishiro M, Katagiri H, Fukushima Y, Kikuchi M, Noguchi N, Aburatani H, Komuro I, Fujita T. Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling. Hypertension 2002; 40 : 872-879.
  39. Ogihara T, Asano T, Ando K, Sakoda H, Anai M, Shojima N, Ono H, Onishi Y, Fujishiro M, Abe M, Fukushima Y, Kikuchi M, Fujita T. High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats. Hypertension 2002; 40 : 83-89.
  40. Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y. Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells. Oncogene 2002 ; 21 : 7042-7049.
  41. Okamoto M, Shiratori Y, Yamaji Y, Kato J, Ikenoue T, Togo G, Yoshida H, Kawabe T, Omata M. Relationship between age and site of colorectal cancer based on colonoscopy findings. Gastrointest Endosc 2002 ; 55 : 548-551.
  42. Omata M, Dan Y, Daniele B, Plentz R, Rudolph KL, Manns M, Piratvisuth T, Chen DS, Tateishi R, Chutaputti A. Clinical features, etiology, and survival of hepatocellular carcinoma among different countries. J Gastroenterol Hepatol 2002 ; 17 (Suppl.) : S40-S49.
  43. Omata M, Yoshida H, Shiratori Y, Shiina S. Progression from chronic hepatitis to hepatocellular carcinoma: Natural course and treatments. J Gastroenterol Hepatol 2002 ; 17 Suppl 3 : S434-S436.
  44. Ono-Nita SK, Kato N, Shiratori Y, Carrilho FJ, Omata M. Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrob Agents Chemother 2002 ; 46 : 2602-2605.
  45. Osada M, Yatomi Y, Ohmori T, Ikeda H, Ozaki Y. Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochem Biophys Res Commun 2002 ; 299 : 483-487.
  46. Osawa E, Nakajima A, Yoshida S, Omura M, Nagase H, Ueno N, Wada K, Matsuhashi N, Ochiai M, Nakagama H, Sekihara H. Chemoprevention of precursors to colon cancer by dehydroepiandrosterone (DHEA). Life Sci 2002 ; 70(22) : 2623-2630.
  47. Otsuka M, Kato N, Taniguchi H, Yoshida H, Goto T, Shiratori Y, Omata M. Hepatitis C Virus Core Protein Inhibits Apoptosis via Enhanced Bcl-x(L) Expression. Virology 2002 ; 296 : 84-93.
  48. Rasmussen SK, Urhammer SA, Berglund L, Jensen JN, Hansen L, Echwald SM, Borch-Johnsen K, Horikawa Y, Mashima H, Lithell H, Cox NJ, Hansen T, Bell GI, Pedersen O. Variants Within the Calpain-10 Gene on Chromosome 2q37 (NIDDM1) and Relationships to Type 2 Diabetes, Insulin Resistance, and Impaired Acute Insulin Secretion Among Scandinavian Caucasians. Diabetes 2002 ; 51 : 3561-3567.
  49. Saito M, Fukushima Y, Tatsumi K, Bei L, Fujiki Y, Iwamori M, Igarashi T, Sakakihara Y. Molecular cloning of Chinese hamster ceramide glucosyltransferase and its enhanced expression in peroxisome-defective mutant Z65 cells. Arch Biochem Biophys 2002 ; 403(2) : 171-178.
  50. Saitoh T, Fukushima Y, Otsuka H, Hirakawa J, Mori H, Asano T, Ishikawa T, Katsube T, Ogawa K, Ohkawa S. Effects of rabeprazole, lansoprazole and omeprazole on intragastric pH in CYP2C19 extensive metabolizers. Aliment Pharmacol Ther 2002 ; 16(10) : 1811-1817.
  51. Saitoh T, Fukushima Y, Otsuka H, Ishikawa M, Tamai M, Takahashi H, Mori H, Asano T, Anai M, Ishikawa T, Katsube T, Ogawa K, Kajiwara T, Omata M, Ohkawa S. Effects of N-alpha-methyl-histamine on human H2 receptors expressed in CHO cells. Gut 2002 ; 50 : 786-789.
  52. Sakoda H, Ogihara T, Anai M, Fujishiro M, Ono H, Onishi Y, Katagiri H, Abe M, Fukushima Y, Shojima N, Inukai K, Kikuchi M, Oka Y, Asano T. Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes. Am J Physiol Endocrinol Metab 2002; 282 : E1239-1244.
  53. Saubermann LJ, Nakajima A, Wada K, Zhao S, Terauchi Y, Kadowaki T, Aburatani H, Matsuhashi N, Nagai R, Blumberg RS. Peroxisome proliferator-activated receptor ? agonist ligands stimulate a Th2 cytokine response and prevent acute colitis. Inflamm Bowel Dis 2002 ; 8(5) : 330-339.
  54. Shiina S, Teratani T, Obi S, Hamamura K, Koike Y, Omata M. Nonsurgical treatment of hepatocellular carcinoma: from percutaneous ethanol injection therapy and percutaneous microwave coagulation therapy to radiofrequency ablation. Oncology 2002 ; 62 Suppl 1:64-68.
  55. Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R. Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med 2002; 8 : 856-863.
  56. Shojima N, Sakoda H, Ogihara T, Fujishiro M, Katagiri H, Anai M, Onishi Y, Ono H, Inukai K, Abe M, Fukushima Y, Kikuchi M, Oka Y, Asano T. Humoral regulation of resistin expression in 3T3-l1 and mouse adipose cells. Diabetes 2002; 51 : 1737-1744.
  57. Song H, Shojima N, Sakoda H, Ogihara T, Fujishiro M, Katagiri H, Anai M, Onishi Y, Ono H, Inukai K, Fukushima Y, Kikuchi M, Shimano H, Yamada N, Oka Y, Asano T. Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules. Biochem Biophys Res Commun 2002; 299 :291-298.
  58. Tada M, Komatsu Y, Kawabe T, Sasahira N, Isayama H, Toda N, Shiratori Y, Omata M. Quantitative analysis of K-ras gene mutation in pancreatic tissue obtained by endoscopic ultrasonography-guided fine needle aspiration: clinical utility for diagnosis of pancreatic tumor. Am J Gastroenterol 2002 ; 97 : 2263-2270.
  59. Tada M, Tateishi K, Kawabe T, Sasahira N, Isayama H, Komatsu Y, Shiratori Y, Omata M. Quantity of mutant K-ras gene in pancreatic secretions for diagnosis of pancreatic carcinoma with different assays: analysis of 100 patients. Clin Chim Acta 2002 ; 324 : 105.
  60. Tateishi K, Takeda K, Mannen T.　Acute disseminated encephalomyelitis confined to brainstem. J Neuroimaging 2002 ; 12(1) : 67-68.
  61. Teratani T, Ishikawa T, Shiratori Y, Shiina S, Yoshida H, Imamura M, Obi S, Sato S, Hamamura K, Omata M. Hepatocellular carcinoma in elderly patients. Cancer 2002 ; 95 : 816-823.
  62. Tomiya T, Inoue Y, Yanase M, Arai M, Ikeda H, Tejima K, Nagashima K, Nishikawa T, Fujiwara K. Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells. Biochem Biophys Res Commun 2002 ; 297 : 1108-1111.
  63. Tsuji T, Suzuki J, Shimamoto R, Yamazaki T, Nakajima T, Nagai R, Komatsu S, Ohtomo K, Toyo-Oka T, Omata M. Vector analysis of the wall shear rate at the human aortoiliac bifurcation using cine MR velocity mapping. Am J Roentgenol 2002 ; 178 : 995-999.
  64. Uchiyama Y, Huang Y, Kanamori H, Uchida M, Doi T, Takamizawa A, Hamakubo T, Kodama T. Measurement of HCV RdRp activity with C-terminal 21 aa truncated NS5b protein: optimization of assay conditions. Hepatol Res 2002 ; 23(2):90-97.
  65. Yamaji Y, Mitsushima T, Ikuma H, Okamoto M, Yoshida H, Kawabe T, Shiratori Y, Saito K, Yokouchi K, Omata M. Weak response of Helicobacter pylori antibody is high risk for gastric cancer: a cross-sectional study of 10,234 endoscoped Japanese. Scand J Gastroenterol 2002 ; 37 : 148-153.
  66. Yoshida H, Arakawa Y, Sata M, Nishiguchi S, Yano M, Fujiyama S, Yamada G, Yokosuka O, Shiratori Y, Omata M. Interferon therapy prolonged life expectancy among chronic hepatitis C patients. Gastroenterology 2002 ; 123 : 483-491.
  67. Yoshida H, Kato N, Shiratori Y, Shao R, Wang Y, Shiina S, Omata M. Weak Association between SEN Virus Viremia and Liver Disease. J Clin Microbiol 2002 ; 40 : 3140-3145.
  68. Akada JK, Ogura K, Dailidiene D, Dailide G, Cheverud JM, Berg DE. Helicobacter pylori tissue tropism: mouse-colonizing strains can target different gastric niches. Microbiology 2003; 149(Pt 7) : 1901-1909.
  69. Fujishiro M, Gotoh Y, Katagiri H, Sakoda H, Ogihara T, Anai M, Onishi Y, Ono H, Abe M, Shojima N, Fukushima Y, Kikuchi M, Oka Y, Asano T. Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes. Mol Endocrinol 2003 ; 17(3) :487-497.
  70. Fujishiro M, Ogihara T, Tsukuda K, Shojima N, Fukushima Y, Kimura S, Oka Y, Asano T. A case showing an association between type 1 diabetes mellitus and Kabuki syndrome. Diabetes Res Clin Pract 2003 ; 60 : 25-31.
  71. Fujita N, Maguchi H, Komatsu Y, Yasuda I, Hasebe O, Igarashi Y, Murakami A, Mukai H, Fujii T, Yamao K, Maeshiro K. Endoscopic sphincterotomy and endoscopic papillary balloon dilation for bile duct stones: a prospective randomized controlled multicenter trial. Gastrointest Endosc 2003; 57 :151-155.
  72. Fujiwara K, Yokosuka O, Imazeki F, Saisho H, Saotome N, Suzuki K, Okita K, Tanaka E, Omata M. Analysis of the genotype-determining region of hepatitis A viral RNA in relation to disease severities. Hepatol Res 2003 ; 25 : 124-134.
  73. Fukushima Y, Ishikawa T, Saitoh T, Tateishi K, Ogihara T, Fujishiro M, Shojima N, Honda M, Kushiyama A, Anai M, Sakoda H, Ono H, Onishi Y, Otsuka H, Katagiri H, Nagai R, Omata M, Asano T. Extremely early onset of ranitidine action on human histamine H2 receptors expressed in HEK293 cells. Digestion 2003; 68 : 145-152.
  74. Fukushima Y, Shindo T, Anai M, Saitoh T, Wang Y, Fujishiro M, Ohashi Y, Ogihara T, Inukai K, Ono H, Sakoda H, Kurihara Y, Honda M, Shojima N, Fukushima H, Haraikawa-Onishi Y, Katagiri H, Shimizu Y, Ichinose M, Ishikawa T, Omata M, Nagai R, Kurihara H, Asano T. Structural and functional characterization of gastric mucosa and central nervous system in histamine H(2) receptor-null mice. Eur J Pharmacol 2003 ; 468 : 47-58.
  75. Goto T, Kato N, Yoshida H, Otsuka M, Moriyama M, Shiratori Y, Koike K, Matsumura M, Omata M. Synergistic activation of the serum response element-dependent pathway by hepatitis B virus x protein and large-isoform hepatitis delta antigen. J Infect Dis 2003 ; 187 : 820-828.
  76. Gunji T, Kawauchi N, Akahane M, Watanabe K, Kanamori H, Ohnishi S. Treatment of unresectable hepatocellular carcinoma less than 2 centimeters by transcatheter arterial chemoembolization with autologous blood clot. J Clin Gastroenterol 2003; 36(4) : 347-351.
  77. Hara K, Ohe K, Kadowaki T, Kato N, Imai Y, Tokunaga K, Nagai R, Omata M. Establishment of a method of anonymization of DNA samples in genetic research.　J Hum Genet　2003;48 : 327-330.
  78. Hasegawa K, Terada S, Kubota K, Itakura H, Imamura H, Ohnishi S, Aoki T, Ijichi M, Saiura A, Makuuchi M. Effect of apolipoprotein E polymorphism on bile lipid composition and the formation of cholesterol gallstone. Am J Gastroenterol 2003 ; 98 :1605-1609.
  79. Hirano K, Shiratori Y, Komatsu Y, Sasahira N, Toda N, Isayama H, Tada M, Tsujino T, Nakata R, Kawase T, Katamoto T, Kawabe T, Omata M. Involvement of the biliary systme in autoimmune pancreatitis: a follow up study. Clin Gastroenterol Hepatol 2003 ; 1 : 453-464.
  80. Ijichi H, Kawabe T, Isayama H, Yamagata M, Imai Y, Tada M, Komatsu Y, Shiratori Y, Omata M, Tanaka K, Midorikawa Y, Kubota K, Makuuchi M. "Duodenal intussusception" due to adenoma of the papilla of Vater. Hepatogastroenterology 2003 ; 50 : 1399-1402.
  81. Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, Inoue Y, Tejima K, Nishikawa T, Omata M, Kimura S, Fujiwara K. Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2003 ; 285 : G880-886.
  82. Ikeda H, Satoh H, Yanase M, Inoue Y, Tomiya T, Arai M, Tejima K, Nagashima K, Maekawa H, Yahagi N, Yatomi Y, Sakurada S, Takuwa Y, Ogata I, Kimura S, Fujiwara K. Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. Gastoenterology 2003; 124 :459-469.
  83. Ikenoue T, Hikiba Y, Kanai F, Tanaka Y, Imamura J, Imamura T, Ohta M, Ijichi H, Tateishi K, Kawakami T, Aragaki J, Matsumura M, Kawabe T, Omata M. Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors. Cancer Res 2003 ; 63 : 8132-8137.
  84. Inoue Y, Komatsu Y, Yoshikawa K, Akahane M, Isayama H, Ohtomo K, Omata M. Biliary motor function in gallstone patients evaluated by fatty-meal MR cholangiography.　J Magn Reson Imaging 2003 ; 18 :196-203.
  85. Isayama H, Komatsu Y, Inoue Y, Toda N, Shiratori Y, Tsujino T, Yamada H, Saitou K, Kawabe T, Omata M. Preserved function of the Oddi sphincter after endoscopic papillary balloon dilation. Hepatogastroenterology 2003 ; 50 : 1787-1791.
  86. Kanda T, Yokosuka O, Kato N, Imazeki F, Fujiwara K, Kawai S, Saisho H, Omata M. Hepatitis A virus VP3 may activate serum response element associated transcription. Scand J Gastroenterol 2003 ; 38 : 307-313.
  87. Kawabe T, Komatsu Y, Isayama H, Takemura T, Toda N, Tada M, Imai Y, Shiratori Y, Omata M. Histological analysis of the papilla after endoscopic papillary balloon dilation. Hepatogastroenterology 2003 ; 50 : 919-923.
  88. Koike Y, Nakagawa K, Shiratori Y, Shiina S, Imamura M, Sato S, Obi S, Teratani T, Hamamura K, Yoshida H, Omata M. Factors affecting the prognosis of patients with hepatocellular carcinoma invading the portal vein--a retrospective analysis using 952 consecutive HCC patients. Hepatogastroenterology 2003 ; 50 : 2035-2039.
  89. Ma J, Nakajima T, Iida H, Iwasawa K, Terasawa K, Oonuma H, Jo T, Morita T, Imuta H, Suzuki J, Hirose K, Okuda Y, Yamada N, Nagai R, Omata M. Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. Eur J Pharmacol 2003 ; 464 : 79-86.
  90. Maru Y, Yokosuka O, Imazeki F, Saisho H, Omata M. Analysis of T cell receptor variable regions and complementarity determining region 3 of infiltrating T lymphocytes in the liver of patients with chronic type B hepatitis. Intervirology 2003 ; 46 : 277-288.
  91. Maruyama T, Mitsui H, Hanajiri K, Sugawara Y, Imamura H, and Makuuchi M. Anti-HBs antibodies produced after liver transplantation: from the donor or the recipient? Hepatology 2003; 38: 271-272.
  92. Masaki T, Shiratori Y, Rengifo W, Igarashi K, Yamagata M, Kurokohchi K, Uchida N, Miyauchi Y, Yoshiji H, Watanabe S, Omata M, Kuriyama S. Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis. Hepatology 2003 ; 37 : 534-543.
  93. Mashima H, Ueda N, Ohno H, Suzuki J, Ohnishi H, Yasuda H, Tsuchida T, Kanamaru C, Makita N, Iiri T, Omata M, Kojima I. A novel mitochondrial Ca2+-dependent solute carrier in the liver identified by mRNA differential display. J Biol Chem 2003 ; 278 : 9520-9527.
  94. Minami M, Atarashi K, Ishiyama A, Hirata Y, Goto A, Omata M. Effects of cholesterol-lowering therapy on pressor hyperreactivity to stress in hypercholesterolemic patients. Hypertens Res 2003 ; 26 : 273-280.
  95. Mitsui H, Nakajima J, Maruyama T, Hanajiri K, Omata M. Clinical efficacy and toxiciy of gefitinib in patients with lung cancer. Lancet 2003 ; 361 : 1993.
  96. Moriyama M, Hoshida Y, Otsuka M, Nishimura S, Kato N, Goto T, Taniguchi H, Shiratori Y, Seki N, Omata M. Relevance Network between Chemosensitivity and Transcriptome in Human Hepatoma Cells. Mol Cancer Ther 2003 ; 2 : 199-205
  97. Murakawa Y. Yamashita T. Ajiki K. Hayami N. Omata M. Nagai R. Effect of cervical vagal nerve stimulation on defibrillation energy: a possible adjunct to efficient defibrillation. Jpn Heart J 2003 ; 44 : 91-100.
  98. Murata K, Lechmann M, Qiao M, Gunji T, Alter HJ, Liang TJ. Immunization with hepatitis C virus-like particles protects mice from recombinat hepatitis C virus-vaccinia infection. Proc Natl Acad Sci 2003; 100 : 6753-6758.
  99. Nakajima T, Ma J, Iida H, Iwasawa K, Jo T, Omata M, Nagai R. 　Inhibitory effects of carvedilol on calcium channels in vascular smooth muscle cells. Jpn Heart J 2003 ; 44 : 963-978.
  100. Ohmori T, Yatomi Y, Osada M, Kazama F, Takafuta T, Ikeda H, and Ozaki Y. Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P(2). Cardiovasc Res 2003; 58 :170-177.
  101. Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y. Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains. Oncogene 2003 ; 22 : 8422-8431.
  102. Omata M. A personal memory (Obituary for Prof. Kunio Okuda). Hepatology 2003 ; 37 : 1235-1236.
  103. Omata M. Study of hepatobiliary disease in the postgenome sequencing era. J Gastroenterol 2003 ; 38 : S67.
  104. Omata M, Yoshida H. Resolution of liver cirrhosis and prevention of hepatocellular carcinoma by interferon therapy against chronis hepatitis C. Scand J Gastroenterol 2003 ; 237(Suppl) : S47-S51.
  105. Onishi Y, Honda M, Ogihara T, Sakoda H, Anai M, Fujishiro M, Ono H, Shojima N, Fukushima Y, Inukai K, Katagiri H, Kikuchi M, Oka Y, Asano T. Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation. Biochem Biophys Res Commun 2003; 303 : 788-794.
  106. Ono H, Shimano H, Katagiri H, Yahagi N, Sakoda H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Viana AY, Fukushima Y, Abe M, Shojima N, Kikuchi M, Yamada N, Oka Y, Asano T. Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement. Diabetes 2003; 52 : 2905-2913.
  107. Otsuka M, Aizaki H, Kato N, Suzuki T, Miyamura T, Omata M, Seki N. Differential cellular gene expression induced by hepatitis B and C viruses. Biochem Biophys Res Commun 2003 ; 300 : 443-447.
  108. Otsuka M, Arai M, Mori M, Kato M, Kato N, Yokosuka O, Ochiai T, Takiguchi M, Omata M, Seki N. Comparing gene expression profiles in human liver, gastric, and pancreatic tissues using full-length-enriched cDNA libraries.　Hepatol Res　2003 ; 27 : 76-82.
  109. Otsuka M, Hoshida Y, Kato N, Moriyama M, Taniguchi H, Arai M, Mori M, Seki N, Omata M. Liver chip and gene shaving. J Gastroenterol 2003 ; 38 : 89-92.
  110. Otsuka M, Kato N, Taniguchi H, Yoshida H, Shiratori Y, Omata M. Signals induced by HCV proteins. In. Okita K, ed. HCV/Oxidative Stress and Liver Disease. Tokyo: Sprnger, 2003 ; 32-47.
  111. Sacco R, Tsutsumi T, Suzuki R, Otsuka M, Aizaki H, Sakamoto S, Matsuda M, Seki N, Matsuura Y, Miyamura T, Suzuki T. Antiapoptotic regulation by hepatitis C virus core protein through up-regulation of inhibitor of caspase-activated DNase. Virology 2003; 317(1) : 24-35.
  112. Shimizu Y, Yamamichi N, Saitoh K, Watanabe A, Ito T, Yamamichi-Nishina M, Mizutani M, Yahagi N, Suzuki T, Sasakawa C, Yasugi S, Ichinose M, Iba H. Kinetics of v-src-induced epithlrial-mesenchymal transition in developing glandular stomach. Oncogene 2003; 22 : 884-893.
  113. Shiratori Y, Shiina S, Teratani T, Imamura M, Obi S, Sato S, Koike Y, Yoshida H, Omata M. Interferon therapy after tumor ablation improves prognosis in patients with hepatocellular carcinoma associated with hepatitis C virus. Ann Intern Med 2003 ; 138 : 299-306.
  114. Sakoda H, Gotoh Y, Katagiri H, Kurokawa M, Ono H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Fukushima Y, Abe M, Shojima N, Kikuchi M, Oka Y, Hirai H, Asano T. Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity. J Biol Chem 2003; 278 : 25802-25807.
  115. Soto G, Bautista CT, Roth DE, Gilman RH, Velapatino B, Ogura M, Dailide G, Razuri M, Meza R, Katz U, Monath TP, Berg DE, Taylor DN; Gastrointestinal Physiology Working Group in Peru. Helicobacter pylori reinfection is common in Peruvian adults after antibiotic eradication therapy. J Infect Dis 2003; 188(9) : 1263-1275.
  116. Takabe K, Wang L, Leal A.M, Macconell LA, Wiater E, Tomiya T, Ohno A, Verma IM, and Vale W. Adenovirus-mediated overexpression of follistatin enlarges intact liver of adult rats. Hepatology 2003; 38 :1107-1115.
  117. Tanaka Y, Takayanagi M, Shiratori Y, Imai Y, Obi S, Tateishi R, Kanda M, Fujishima T, Akamatsu M, Koike Y, Hamamura K, Teratani T, Ishikawa T, Shiina S, Kojiro M, Omata M. Congenital absence of portal vein with multiple hyperplastic nodular lesions in the liver (Case report). J Gastroenterol 2003 ; 38 : 288-294.
  118. Tang W, Miki K, Kokudo N, Sugawara Y, Imamura H, Minagawa M, Yuan LW, Ohnishi S, Makuuchi M. Des-gamma-carboxy prothrombin in cancer and non-cancer liver tissue of patients with hepatocellular carcinoma. Int J Oncol 2003 ; 22:969-975.
  119. Wang Y, Kato N, Hoshida Y, Yoshida H, Taniguchi H, Goto T, Moriyama M, Otsuka M, Shiina S, Shiratori Y, Ito Y, Omata M. Interleukin-1beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection. Hepatology 2003 ; 37 : 65-71.
  120. Watabe H, Shiratori Y, Tateishi R, Fujishima T, Akamatsu M, Koike Y, Obi S, Hamamura K, Sato S, Teratani T, Shiina S, Omata M. Clinical features of patients with HCC who are negative for both HBV and HCV markers. Hepatogastroenterology 2003 ; 50 : 2157-2160.
  121. Yahagi N, Fujishiro M, Iguchi M, Kakushima N, Omata M. Theoretical and technical requirements to expand EMR indications. Digestive Endoscopy 2003; 15 : S19-S21.
  122. Yamada S, Tomiya T, Yamaguchi Y, Hiura M, Otsuki M. Activation of hepatic macrophage contributes to hepatic necrosis after post-ischemic reperfusion in alcoholic fatty liver. Hepatol Res 2003; 26 :209-216.
  123. Yamashiki N, Kato T, Bejarano PA, Berho M, Montalvo B, Shebert RT, Goodman ZD, Seki T, Schiff ER, Tzakis AG. Histopathological changes after microwave coagulation therapy for patients with hepatocellular carcinoma: Review of 15 explanted livers. Am J Gastroenterol 2003; 98: 2052-2059.
  124. Yanai A, Hirata Y, Mitsuno Y, Maeda S, Shibata W, Akanuma M, Yoshida H, Kawabe T, Omata M. Helicobacter pylori Induces Antiapoptosis through Nuclear Factor-kappaB Activation. J Infect Dis 2003 ; 188 : 1741-1751.
  125. Yanase M, Ikeda H, Ogata I, Matsui A, Noiri E, Tomiya T, Arai M, Inoue Y, Tejima K, Nagashima K, Nishikawa T, Shibata M, Ikebe M, Rojkind M, Fujiwara K. Functional diversity between Rho-kinase- and MLCK-mediated cytoskeletal actions in a myofibroblast-like hepatic stellate cell line. Biochem Biophys Res Commun 2003; 305 :223-228.
  126. Akamatsu M, Yoshida H, Shiina S, Teratani T, Tateishi R, Obi S, Sato S, Koike Y, Fujishima T, Ishikawa T, Shiratori Y, Omata M. Neither hepatitis C virus genotype nor virus load affects survival of patients with hepatocellular carcinoma. Eur J Gastroenterol Hepatol 2004 ; 16 : 459-466.
  127. Dailidiene D, Dailide G, Ogura K, Zhang M, Mukhopadhyay AK, Eaton KA, Cattoli G, Kusters JG, Berg DE. Helicobacter acinonychis: genetic and rodent infection studies of a Helicobacter pylori-like gastric pathogen of cheetahs and other big cats. J Bacteriol 2004 ; 186(2) : 356-365.
  128. Ijichi H, Otsuka M, Tateishi K, Ikenoue T, Kawakami T, Kanai F, Arakawa Y, Seki N, Shimizu K, Miyazono K, Kawabe T, Omata M. Smad4-independent regulation of p21/WAF1 by transforming growth factor-beta. Oncogene 2004 ; 23 :1043-1051.
  129. Ikai I, Itai Y, Okita K, Omata M, Kojiro M, Kobayashi K, Nakanuma Y, Futagawa S, Makuuchi M, Yamaoka Y. Report of the 15th follow-up survey of primary liver cancer. Hepatol Res 2004 ; 28 : 21-29.
  130. Ikenoue T, Hikiba Y, Kanai F, Ijichi H, Togo G, Ohta M, Watabe H, Yamaji Y,　Okamoto M, Aragaki J, Matsumura M, Kawabe T, Omata M. Rapid detection of mutations in the BRAF gene using real-time polymerase chain reaction and melting curve analysis.　Cancer Genet Cytogenet 2004 ; 149 : 68-71.
  131. Isayama H, Komatsu Y, Tsujino T, Sasahira N, Hirano K, Toda N, Nakai Y, Yamamoto N, Tada M, Yoshida H, Shiratori Y, Kawabe T, Omata M. A prospective randomised study of "covered" versus "uncovered" diamond stents for the management of distal malignant biliary obstruction. Gut 2004 ; 53 : 729-734.
  132. Kakushima N, Fujishiro M, Yahagi N, Oka M, Kobayashi K, Hashimoto T, Miyoshi H, Moriyama Y, Enomoto S, Iguchi M, Ichinose M, Omata M. An unusual case of polypoid angiodysplasia.　Endoscopy 2004 ; 36 : 379.
  133. Kakushima N, Kamoshida T, Hirai S, Hotta S, Hirayama T, Yamada J, Ueda K, Sato M, Okumura M, Shimokama T, Oka Y. A Case of early gastric with Krukenberg and review of cases of intramucosal gastric cancers Krukenberg tumor. J Gastroenterol 2004; 38 (12) : 1176-1180.
  134. Kamijo A, Kimura K, Sugaya T, Yamanouchi M, Hikawa A, Hirano N, Hirata Y,　Goto A, Omata M. Urinary fatty acid-binding protein as a new clinical marker of the progression of chronic renal disease. J Lab Clin Med 2004 ; 143 : 23-30.
  135. Miyashita K, Tojo A, Kimura K, Goto A, Omata M, Nishiyama K, Fujita T. Blood pressure response to erythropoietin injection in hemodialysis and predialysis patients. Hypertens Res 2004 ; 27 : 79-84.
  136. Omata M, Yoshida H. Prevention and treatment of hepatocellular carcinoma. Liver Transpl 2004 ;10(2 Suppl 1) : S111-114.
  137. Sato S, Shiratori Y, Imamura M, Obi S, Shiina S, Akahane M, Ohtomo K, Omata M. Re-appearance of power Doppler signals in the tumor nodules of hepatocellular carcinoma after transarterial embolization reflects residual viable tumor cells:histological confirmation. Hepatogastroenterology 2004 ; 51 : 56-61.
  138. Satonaka H, Suzuki E, Nishimatsu H, Oba S, Takeda R, Goto A, Omata M, Fujita T, Nagai R, Hirata Y. Calcineurin promotes the expression of monocyte chemoattractant protein-1 in vascular myocytes and mediates vascular inflammation. Circ Res 2004 ; 94 : 693-700.
  139. Taniguchi H, Kato N, Otsuka M, Goto T, Yoshida H, Shiratori Y, Omata M. Hepatitis C virus core protein upregulates transforming growth factor-beta 1 transcription. J Med Virol 2004 ; 72 : 52-59.
  140. Tomiya T, Omata M, Fujiwara K. Significance of branched chain amino acids as possible stimulators of hepatocyte growth factor. Biochem Biophys Res Commun 2004 ; 313 : 411-416.
  141. Wang Y, Kato N, Hoshida Y, Otsuka M, Taniguchi H, Moriyama M, Shiina S, Kawabe T, Ito YM, Omata M. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in japanese patients with hepatitis C virus infection. Clin Cancer Res 2004 ; 10 : 2441-2446.
  142. Yahagi N, Fujishiro M, Kakushima N, Hashimoto T, Kobayashi K, Oka M, Iguchi M, Enomoto S, Ichinose M, Niwa H, Omata M. Endoscopic submucosal dissection for early gastric cancer using the tip of an electro-sergical snare (thin type). Digestive Endoscopy 2004; 16 : 34-38.
  143. Yamaji Y, Mitsushima T, Ikuma H, Watabe H, Okamoto M, Kawabe T, Wada R, Doi H, Omata M. Incidence and recurrence rates of colorectal adenomas estimated by annually repeated colonoscopies on asymptomatic Japanese. Gut 2004 ; 53 : 568-572.
  144. Yanase M, Ikeda H, Matsui A, Noiri E, Tomiya T, Arai M, Inoue Y, Tejima K, Nagashima K, Nishikawa T, Shibata M, Kimura S, Fujiwara K, Rojkind M, Ogata I. HMG-CoA reductase inhibitor modulates collagen gel-contraction by hepatic myofibroblast-like stellate cell line. Comp Hepatol 2004; 3 (suppl) : S21.
  145. Yoshida H, Tateishi R, Arakawa Y, Sata M, Fujiyama S, Nishiguchi S,Ishibashi H, Yamada G, Yokosuka O, Shiratori Y, Omata M. Benefit of interferon therapy in hepatocellular carcinoma prevention for individual patients with chronic hepatitis C. Gut 2004 ; 53 : 425-430.
Annual Report of the Graduate School of Medicine and The Faculty of Medicine The University of Tokyo Reports for the Period April 2002 - March 2004