Department of Geriatrics

References

  1. Ahn JD, Morishita R, Kaneda Y, Lee SJ, Kwon KY, Choi SY, Lee KU, Park JY, Moon IJ, Park JG, Yoshizumi M, Ouchi Y, Lee IK: Inhibitory effects of novel AP-1 decoy oligodeoxynucleotides on vascular smooth muscle cell proliferation in vitro and neointimal formation in vivo. Circ Res 90: 1325-1332, 2002
  2. Akishita M, Toba K, Nagano K, Ouchi Y: Adverse drug reactions in older people with dementia. J Am Geriatr Soc 50: 400-401, 2002
  3. Ako J, Kozaki K, Yoshizumi M, Ouchi Y: Transient left ventricular apical ballooning without coronary artery stenosis: a form of stunning-like phenomenon? J Am Coll Cardiol 39: 741-742, 2002
  4. Aoki-Nagase T, Nagase T, Oh-Hashi Y, Shindo T, Kurihara Y, Yamaguchi Y, Yamamoto H, Tomita T, Ohga E, Nagai R, Kurihara H, Ouchi Y: Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice. Am J Physiol Lung Cell Mol Physiol 283: L963-970, 2002
  5. Amiya E, Ako J, Kozaki K, Iijima K, Nagase T, Ouchi Y: Yellow nail syndrome in an elderly man. Geriat Gerontol Int 2: 157-160, 2002
  6. Cosentino F, Bonetti S, Rehorik R, Eto M, Werner-Felmayer G, Volpe M, Luscher TF: Nitric-oxide-mediated relaxations in salt-induced hypertension: effect of chronic beta1 -selective receptor blockade. J Hypertens 20: 421-428, 2002
  7. Eto M, Kozai T, Cosentino F, Joch H, Luscher TF. Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways. Circulation 105: 1756-1759, 2002
  8. Fujita M, Ogawa S, Fukuoka H, Tsukui T, Nemoto N, Tsutsumi O, Ouchi Y, Inoue S: Differential expression of secreted frizzled related protein 4 (sFRP4) in decidual cells during pregnancy. J Mol Endocrinol 28: 213-223, 2002
  9. Fujita M, Urano T, Horie K, Ikeda K, Tsukui T, Fukuoka H, Tsutsui O, Ouchi Y, Inoue S: Estrogen activates cyclin-dependent kinases 4 and 6 through induction of cyclin D in rat primary osteoblasts. Biochem Biophys Res Commun 299: 222-228, 2002
  10. Hashimoto M, Miyao M, Akishita M, Hosoi T, Toba K, Kozaki K, Yoshizumi M, Ouchi Y: Effects of long-term and reduced-dose hormone replacement therapy on endothelial function and intima-media thickness in postmenopausal women. Menopause 9: 58-64, 2002
  11. Iijima K, Yoshizumi M, Ouchi Y: Effect of red wine polyphenols on vascular smooth muscle cell function--molecular mechanism of the 'French paradox'. Mech Ageing Dev 123: 1033-1039, 2002
  12. Iijima K, Yoshizumi M, Hashimoto M, Akishita M, Kozaki K, Ako J, Watanabe T, Ohike Y, Son B, Yu J, Nakahara K, Ouchi Y: Red wine polyphenols inhibit vascular smooth muscle cell migration through two distinct signaling pathways. Circulation 105: 2404-2410, 2002
  13. Jin GB, Hong T, Inoue S, Urano T, Cho S, Otsu K, Kitahara M, Ouchi Y, Cyong JC: Augmentation of immune cell activity against tumor cells by Rauwolfia radix. J Ethnopharmacol 81: 365-372, 2002
  14. Jin GB, Inoue S, Urano T, Cho S, Ouchi Y, Cyong JC: Induction of anti-metallothionein antibody and mercury treatment decreases bone mineral density in mice. Toxicol Appl Pharmacol 185: 98-110, 2002
  15. Kageyama A, Hirano T, Kageyama H, Osaka T, Namba Y, Tsuji M, Adachi M, Inoue S: Distinct role of adiposity and insulin resistance in glucose intolerance: studies in ventromedial hypothalamic-lesioned obese rats. Metabolism 51: 716-23, 2002
  16. Kozaki K, Kaminski WE, Tang J, Hollenbach S, Lindahl P, Sullivan C, Yu JC, Abe K, Martin PJ, Ross R, Betsholtz C, Giese NA, Raines EW: Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice. Am J Pathol 161: 1395-1407, 2002
  17. Kume H, Teramoto S, Isurugi K. In-vivo dedifferentiation of keratinocytes to epidermal stem cells.Lancet 359: 528-529, 2002
  18. Kurosawa T, Hiroi H, Tsutsui O, Ishikawa T, Osuga Y, Fujiwara T, Inoue S, Muramatsu M, Momoeda M, Taketani Y: The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type. Endocr J 49: 465-471, 2002
  19. Liang YQ, Akishita M, Kim S, Ako J, Hashimoto M, Iijima K, Ohike Y, Watanabe T, Sudoh N, Toba K, Yoshizumi M, Ouchi Y: Estrogen receptor beta is involved in the anorectic action of estrogen. Int J Obes Relat Metab Disord 26: 1103-1109, 2002
  20. Nagase T, Uozumi N, Ishii S, Kita Y, Yamamoto H, Ohga E, Ouchi Y, Shimizu T: A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nat Med 8: 480-484, 2002
  21. Nagase T, Ishii S, Shindou H, Ouchi Y, Shimizu T: Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway. Am J Respir Crit Care Med 165: 200-205, 2002
  22. Ogawa S, Emi M, Shiraki M, Hosoi T, Orimo H, Ouchi Y, Inoue S: Association of amino acid variation (Trp64Arg) in the beta3-adrenergic receptor gene with bone mineral density. Geriatric Gerontol Int 2: 138-142, 2002
  23. Ogihara T, Morimoto S, Okaishi K, Hiwada K, Matsuoka H, Matsumoto M, Takishita S, Shimamoto K, Shimada K, Abe I, Kohara K, Ouchi Y: Questionnaire survey on the Japanese guidelines for treatment of hypertension in the elderly: 1999 revised version. Hypertens Res 25: 69-75, 2002
  24. Otsuka M, Yamaguchi K, Ueki A: Similarities and differences between Alzheimer's disease and vascular dementia from the viewpoint of nutrition. Ann N Y Acad Sci 977: 155-161, 2002
  25. Sahara M, Inoue S, Sunaga S, Kitagawa H, Ako J, Hoshino S, Toba K, Ouchi Y: Megakaryoblastic transformation of chronic myelomonocytic leukemia, presenting with severe bone pain. Geriatric Gerontol Int 2: 105-109, 2002
  26. Sata M, Takahashi A, Tanaka K, Washida M, Ishizaka N, Ako J, Yoshizumi M, Ouchi Y, Taniguchi T, Hirata Y, Yokoyama M, Nagai R, Walsh K: Mouse genetic evidence that tranilast reduces smooth muscle cell hyperplasia via a p21(WAF1)-dependent pathway. Arterioscler Thromb Vasc Biol 22: 1305-1309, 2002
  27. Sugiyama H, Ogawa S, Emi M, Shiraki M, Hosoi T, Orimo H, Ouchi Y, Inoue S: Ethnic difference in contribution of alleles of the interleukin-1 receptor antagonist gene to preposition to osteoporosis. Geriatric Gerontol Int 2: 87-90, 2002
  28. Teramoto S, Kume H, Ouchi Y. Altered Swallowing Physiology and Aspiration in COPD. Chest 122: 1104-1105, 2002
  29. Teramoto S, Kume H, Ouchi Y: Nocturnal gastroesophageal reflux: symptom of obstructive sleep apnea syndrome in association with impaired swallowing. Chest 122: 2266-2267, 2002
  30. Teramoto S, Inoue Y, Ouchi Y: Clinical significance of sleep apnea syndrome in the elderly. Geriatr Gerontol Int 2: 163-171, 2002
  31. Teramoto S, Ishii T, Matsuse T: Genetic susceptibility to tobacco smoke toxicity and chronic obstructive pulmonary disease. Geriatr Gerontol Int 2: 1-7, 2002
  32. Teramoto S, Kume H, Matsuse T: Ambulatory blood pressure after sleep apnoea treatment. Lancet 360: 341-342, 2002
  33. Teramoto S, Matsuse T, Fukuchi Y: Clinical significance of nocturnal oximeter monitoring for detection of sleep apnea syndrome in the elderly. Sleep Med 3: 67-71, 2002
  34. Tomita T, Nagase T, Ohga E, Yamaguchi Y, Yoshizumi M, Ouchi Y: Molecular mechanisms underlying human beta-defensin-2 gene expression in a human airway cell line (LC2/ad). Respirology 7: 305-310, 2002
  35. Urano T, Saito T, Tsukui T, Fujita M, Hosoi T, Muramatsu M, Ouchi Y, Inoue S: Efp targets 14-3-3sigma for proteolysis and promotes breast tumour growth. Nature 417: 871-875, 2002
  36. Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T, Kurihara H, Ouchi Y: Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. J Immunol 169: 2516-2523, 2002
  37. Ako J, Ikari Y, Hatori M, Hara K, Ouchi Y: Changing spectrum of infective endocarditis: review of 194 episodes over 20 years. Circ J 67: 3-7, 2003
  38. Aoki T, Inoue S, Imamura H, Fukushima J, Takahashi S, Urano T, Hasegawa K, Ogushi T, Ouchi Y, Makuuchi M: EBAG9/RCAS1 expression in hepatocellular carcinoma: Correlation with tumour dedifferentiation and proliferation. Eur J Cancer 39: 1552-1561, 2003
  39. Cosentino F, Eto M, De Paolis P, van der Loo B, Bachschmid M, Ullrich V, Kouroedov A, Delli Gatti C, Joch H, Volpe M, Luscher TF: High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species. Circulation 107: 1017-1023, 2003
  40. Daida H, Ouchi Y, Saito Y, Yamada N, Nishide T, Mokuno H, Kurata T, Sato H, Eto M, Ako J, Tango T, Yamaguchi H, Coronary Atherosclerosis and Lipid Research Group: Preventing angiographic progression of coronary atherosclerosis with pravastatin. J Atheroscler Thromb 10: 25-31, 2003
  41. Eto M, Toba K, Akishita M, Kozaki K, Watanabe T, Kim S, Hashimoto M, Sudoh N, Yoshizumi M, Ouchi Y: Reduced endothelial vasomotor function and enhanced neointimal formation after vascular injury in a rat model of blood pressure lability. Hypertens Res 26: 991-998, 2003
  42. Eto M, Luscher TF: Modulation of coagulation and fibrinolytic pathways by statins. Endothelium 10: 35-41, 2003
  43. Ezura Y, Nakajima T, Kajita M, Ishida R, Inoue S, Yoshida H, Suzuki T, Shiraki M, Hosoi T, Orimo H, Emi M: Association of molecular variants, haplotypes, and linkage disequilibrium within the human vitamin D-binding protein (DBP) gene with postmenopausal bone mineral density. J Bone Miner Res 18: 1642-1649, 2003
  44. Hoshino S, Hosoi T, Shiraki M, Orimo H, Ouchi Y, Inoue S: Association of Tumor Necrosis Factor 1 (TNFR1) gene polymorphism with bone mineral density. Geriatric Gerontol Int 3: 101-105, 2003
  45. Ishida R, Emi M, Ezura Y, Iwasaki H, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Ito H, Orimo H: Association of a haplotype (196Phe/532Ser) in the interleukin-1-receptor-associated kinase (IRAK1) gene with low radial bone mineral density in two independent populations. J Bone Miner Res 18: 419-423, 2003
  46. Ishida R, Ezura Y, Emi M, Kajita M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Ito H, Orimo H: Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women. Bone 33: 237-241, 2003
  47. Ishii T, Fujishiro M, Masuda M, Nakajima J, Teramoto S, Ouchi Y, Matsuse T: Depletion of glutathione S-transferase P1 induces apoptosis in human lung fibroblasts. Exp Lung Res 29: 523-536, 2003
  48. Iwasaki H, Emi M, Ezura Y, Ishida R, Kajita M, Kodaira M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Swensen J, Orimo H: Association of a Trp16Ser variation in the gonadotropin releasing hormone (GnRH) signal peptide with bone mineral density, revealed by SNP-dependent PCR (Sd-PCR) Typing. Bone 32: 185-190, 2003
  49. Jin GB, Nakayama H, Shmyhlo M, Inoue S, Kondo M, Ikezawa Z, Ouchi Y, Cyong JC: High positive frequencies of antibodies to metallothionein and heat shock protein 70 in sera of patients with metal allergy. Clin Exp Immunol 131: 275-279, 2003
  50. Kajita M, Ezura Y, Iwasaki H, Ishida R, Yoshida H, Kodaira M, Suzuki T, Hosoi T, Inoue S, Shiraki M, Orimo H, Emi M: Association of -381T/C promoter cariation of brain natriuretic peptide gene with low bone mineral density and rapid postmenopausal bone loss. J Hum Genet 48: 77-81, 2003
  51. Kageyama H, Osaka T, Kageyama T, Kawada T, Hirano T, Oka J, Miura M, Namba Y, Ricquier D, Shioda S, Inoue S: Fasting increases gene expressions of uncoupling proteins and peroxisome proliferator-activated receptor-gamma in brown adipose tissue of ventromedial hypothalamus-lesioned rats. Life Sci 72: 3035-46, 2003
  52. Kageyama H, Kamegaya A, Endo Y, Osaka T, Nemoto K, Hirano T, Namba Y, Shioda S, Inoue S: Ventromedial hypothalamus lesions induce jejunal epithelial cell hyperplasia through an increase in gene expression of cyclooxygenase. Int J Obes Relat Metab Disord 27: 1006-13, 2003
  53. Kanazawa M, Xue CY, Kageyama H, Suzuki E, Ito R, Namba Y, Osaka T, Kimura S, Inoue S: Effects of a high-sucrose diet on body weight, plasma triglycerides, and stress tolerance. Nutr Rev 61(5 Pt 2): S27-33, 2003
  54. Mizuno Y, Namba Y: Aging society and the adult guardianship system. Geriatr Gerontol Int 3: 225-235, 2003
  55. Nagase T, Uozumi N, Aoki-Nagase T, Terawaki K, Ishii S, Tomita T, Yamamoto H, Hashizume K, Ouchi Y, Shimizu T: A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 284: L720-726, 2003
  56. Nakamura T, Akishita M, Kozaki K, Toba K, Orimo H, Ouchi Y. Influence of sex and estrogen on vitamin D-induced arterial calcification in rats. Geriatric Gerontol Int 3: 145-149, 2003
  57. Ogihara T, Hiwada K, Morimoto S, Matsuoka H, Matsumoto M, Takishita S, Shimamoto K, Shimada K, Abe I, Ouchi Y, Tsukiyama H, Katayama S, Imai Y, Suzuki H, Kohara K, Okaishi K, Mikami H: Guidelines for treatment of hypertension in the elderly--2002 revised version. Hypertens Res 26: 1-36 2003
  58. Ohga E, Tomita T, Wada H, Yamamoto H, Nagase T, Ouchi Y: Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1. J Appl Physiol 94: 179-184, 2003
  59. Ohtoh T, Ono Y, Iwasaki Y, Sakurai Y, Nishino A, Arai H, Suzuki H, Namba Y: Non-traumatic recurrent dissection and its spontaneous repair in the circle of Willis: Report of two autopsy cases. Neuropathology 23: 195-198, 2003
  60. Okada S, Teramoto S, Takizawa H, Ouchi Y, Matsuoka R: Clinical insignificance of (1-->3)-beta-D-glucan in early diagnosis of invasive pulmonary aspergillosis in a patient with chronic obstructive pulmonary disease. J Med Microbiol 52(Pt 11): 1031-1032, 2003
  61. Omasu F, Emi M, Ezura Y, Kajita M, Ishida R, Kodaira M, Yoshida H, Suzuki, Hosoi T, Inoue S, Shiraki M, Orimo H: Association of genetic variation of gene encoding LIM domain protein (RIL) with low bone mineral density in postmenopausal Japanese women. J Hum Genet 48: 342-345, 2003
  62. Tabb MM, Sun A, Zhou C, Grun F, Errandi JL, Romero KM, Pham H, Inoue S, Mallick S, Lin M, Forman BM, Blumberg B: Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor, SXR. J Biol Chem 278: 43919-43927, 2003
  63. Takahashi S, Urano T, Tsuchiya F, Fujimura T, Kitamura T, Ouchi Y, Muramatsu M, Inoue S: EBAG9/RCAS1 expression and its prognostic significance in prostatic cancer. Int J Cancer 106: 310-315, 2003
  64. Teramoto S, Kume H, Ishii T, Mastsue T: Production of oxygen radicals by peripheral blood neutrophils is increased in patients with stable asthma and during exacerbations. Respiration 69: 286-287, 2003
  65. Teramoto S, Kume H, Matsuse T, Ishii T, Miyashita A, Akishita M, Toba K, Ouchi Y: Oxygen administration improves the serum level of nitric oxide metabolites in patients with obstructive sleep apnea syndrome. Sleep Med 4: 403-407, 2003
  66. Teramoto S, Kume H, Yamamoto H, Ishii T, Miyashita A, Matsuse T, Akishita M, Toba K, Ouchi Y: Effects of oxygen administration on the circulating vascular endothelial growth factor (VEGF) levels in patients with obstructive sleep apnea syndrome. Intern Med 42: 681-685, 2003
  67. Teramoto S, Yamamoto H, Ouchi Y: Increased C-reactive protein and increased plasma interleukin-6 may synergistically affect the progression of coronary atherosclerosis in obstructive sleep apnea syndrome. Circulation 107: E40-0, 2003
  68. Teramoto S, Kume H, Matsuse T, Ishii T, Miyashita A, Akishita M, Toba K, Ouchi Y: Oxygen administration improves the serum level of nitric oxide metabolites in patients with obstructive sleep apnea syndrome. Sleep Med 4: 403-407, 2003
  69. Teramoto S, Yamamoto H, Ouchi Y: Clinical efficacy and toxicity of gefitinib in patients with lung cancer. Lancet 361: 1992-1993, 2003
  70. Teramoto S, Yamamoto H, Yamaguchi Y, Kawaguchi H, Ouchi Y: Nosocomial infections in adult intensive-care units. Lancet 362: 493, 2003
  71. Teramoto S, Yamamoto H, Yamaguchi Y, Matsuse T, Ouchi Y: Global burden of COPD in Japan and Asia. Lancet 362: 1764-1765, 2003
  72. Tsurusaki T, Aoki D, Kanetake H, Inoue S, Muramatsu M, Hishikawa Y, Koji T: Zone-dependent expression of estrogen receptor alpha and beta in human benign prostatic hyperplasia. J Clin Endocrinol Metab 88: 1333-1340, 2003
  73. Watanabe T, Akishita M, He H, Miyahara Y, Nagano K, Nakaoka T, Yamashita N, Kozaki K, Ouchi Y: 17 beta-estradiol inhibits cardiac fibroblast growth through both subtypes of estrogen receptor. Biochem Biophys Res Commun 311: 454-459, 2003
  74. Watanabe T, Akishita M, Nakaoka T, Kozaki K, Miyahara Y, He H, Ohike Y, Ogita T, Inoue S, Muramatsu M, Yamashita N, Ouchi Y: Estrogen receptor beta mediates the inhibitory effect of estradiol on vascular smooth muscle cell proliferation. Cardiovasc Res 59: 734-744, 2003

Annual Report of the Graduate School of Medicine and The Faculty of Medicine The University of Tokyo Reports for the Period April 2002 - March 2004