|
Department of Urology
Professor
Tadaichi Kitamura, M.D. (Oncology, Nephrology, Urolithiasis, Virology)
Associate Professor
Takumi Takeuchi, M.D. (Transplantation, Immunology, Oncology) Satoru Takahashi,
M.D. (Neurourology, Female urology, Oncology)
Lecturer
Kyoichi Tomita, M.D. (Oncology) Haruki Kume, M.D. (Oncology, Nephrology)
Hiroaki Nishimatsu, M.D. (Endocrinology, Neurourology) Akira Ishikawa, M.D.
(Transplantation, Nephrology)
Associate
Naohiko Okamoto, M.D. (Nephrology, Urolithiasis) Shinya Matsumoto, M.D.
(Oncology)
Yutaka Enomoto, M.D. (Virology, Oncology) Hiroshi Yokoyama, M.D. (Nephrology)
Akira Nomiya, M.D. (Pediatric Urology) Aya Niimi, M.D. (Oncology)
Yusuke Sato, M.D. (Neurourology) Fumitake Kobayashi, M.D. (Oncology)
Yuta Takeshima, M.D. (Nephrology) Yuta Yamada, M.D. (Oncology)
Shizue Nyoumura, M.D. (Female Urology)
Organization
Urology is a special field of clinical medicine covering the diseases of the
adrenal gland, the kidney, the urinary tract and the male genital system by
means of a surgical procedure as well as an approach of internal medicine. In
addition, urology encompasses pediatric urology, neurourology, female urology
(especially, stress incontinence), renal transplantation, renal vascular
surgery, endocrine surgery and geriatric urology. For this reason, urology
requires the scientific background of oncology, nephrology, endocrinology,
andrology, immunology, pediatrics, histology, microbiology, neurology and
gerontology. Now we have commenced to utilize cellular and molecular biology to
develop the research in urology. It is expected for our department to devote to
the scientific progress in the frontier of urology.
In recent years, we have been taking international leadership in applying the
new and minimally invasive treatment modalities. They are exemplified by
endoscopic management of the diseases in the upper urinary tract, ESWL, or laser
lithotripsy for urolithiasis, hyperthermic and laser therapies for BPH, and
laparoscopic adrenalectomy and nephrectomy substituting open procedures.
The professor, associate professors, instructors and associates are involved in
in-patient and out-patient cares and teaching of the students as well as
research activities. Clinical visiting professors are mainly engaged in the
teaching.
Research Activities
There are 9 research groups with different clinical and research activities
shown as follows. Our basic principles for research are in accord with the
trends in modern medicine; improvement of quality of life, minimally invasive
treatment, application of modern technology and/or basic science and
cost-effectiveness. There are approximately 25 publications in English each
year.
Nephrology group
Urolithiasis group
Transplantation group
Oncology group
Endourology group
Neurourology and Geriatric urology group
Andrology and Endocrinology group
Immunology group
Virology group
Teaching Activities
Systematic urological lectures are provided for the second year medical
students. Both clinical lectures and bed side teaching are scheduled for the
third and fourth year medical students. Thirteen times of systematic lectures
are performed by professor, associate professors and instructors concerning
their specialties.
Bed side teaching is concentrated on practical care of the patients. Teachers
give lectures mainly regarding pre-and post-operative management, indication of
operation, surgical anatomy and surgical techniques.
Clinical Activities
There are 44 beds in the ward (8th floor of the central-ward-building). The
residents take care of all the patients on 24-hour a day basis. Associate staff
members team up with the residents on a man-to-man basis. The total number of
inpatients was 601 from April 2003 to March 2004. More than half of in-patients
suffer from urogenital cancer. Urolithiasis, benign prostatic hyperplasia,
urinary incontinence and other many diseases were treated.
Elective operations are performed on Tuesday, Wednesday and Thursday. A total of
1025 operations were performed in 2003. The main operations are total cystectomy
7 (ileal neobladder 3), total prostatectomy 82, radical nephrectomy 26,
transurethral resection of the bladder tumor (TUR-Bt) 90, transurethral
resection of the prostate (TUR-P) 36, transurethral lithotripsy (TUL) 20, and
ESWL 76.
A weekly clinical conference is held for discussing cases with difficult
problems in detail and the best treatment is chosen for each case. Furthermore
at the weekly professor's round on Wednesday, data of all the patients are
presented and appropriate treatment strategies are recommended for them.
In out-patient clinic, services are provided from Monday to Friday. Patients
assigned to specialized service as andrology, neurourology and transplantation
receive sophisticated care on the particular day of the week.
The number of newly registered patients was 1108 and the total number of
out-patients was 27556 patient-days from April 2003 to March 2004.
References
- Homma Y, Yamaguchi T, Kondo Y, Horie S, Takahashi S, Kitamura T.
Significance of nocturia in the international prostate symptom score for
benign prostatic hyperplasia. Int J Urol 167: 172-176, 2002
- Matsushima H, Kawabe K, Fujime M, Kitamura T, Homma Y, Kishi H, Kawamura
T, Umeda T, Ohishi Y, Murai M, Kawai T, Yoshida H, Fukuda T. Treatment of
patients with superficial bladder cancer by intravesical instillation of
anticancer drugs plus oral chemotherapy following TUR-Bt : A randomized
controlled trial. Oncol Rep 9 : 283-288, 2002
- Kitamura T, Nishimatsu H, Hamamoto T, Tomita K, Takeuchi T, Ohta N. EMP
combination chemotherapy and low-dose monotherapy in advanced prostate
cancer. Expert Rev Anticancer Ther 2: 59-71, 2002
- Sugimoto C, Hasegawa M, Kato A, Zheng H-Y, Ebihara H, Taguchi F,
Kitamura T, Yogo Y. Evolution of human polyomavirus JC : Implications
for the population history of humans. J Mol Evol 54 : 285-297, 2002
- Ohashi Y, Nakai S, Tsukamoto T, Masumori N, Akaza H, Miyanaga N,
Kitamura T, Kawabe K, Kotake T, Kuroda M, Naito S, Koga H, Saito Y, Nomata
K, Kitagawa M. Habitual intake of lactic acid bacteria and risk reduction of
bladder cancer. Urol Int 62 : 273-280, 2002
- Hirasawa K, Kitamura T, Oka T, Matsushita H. Bladder tumor
producing granulocyte colony stimulating factor and parathyroid hormone
related protein. J Urol, 167 : 2130, 2002
- Kaneko T, Kurimoto S, Kume H, Kitamura T. Accidental resection of
bilateral ureteric orfices in a patient with ureterosigmoidostomy. BJU Int
89 : 969-970, 2002
- Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K, Kitamura T,
Kurabayashi M, Nagai R, Higashihara E, Harris PC, Katsuki M, Horie S.
Pioglitazone improves the phenotype and molecular defects of a targeted PKd1
mutant. Hum Molec Genet 11: 1731-1742, 2002
- Hamamoto T, Beppu H, Okada H, Kawabata M, Kitamura T, Miyazono K, Kato
K. Compound disruption of Smad 2 accelerates malignant progression of
intestinal tumors in Apc knockout mice. Cancer Res 62: 5955-5961. 2002
- Saruwatari L, Zheng H-Y, Takasaka T, Sugimoto C, Sakai E, Bo B, Aung N
N, Kitamura T, Yogo Y, Ohno N. Peopling of Myanmar as Demonstrated
by Genotyping of Urinary JC Virus DNA. Anthropological Science 110: 235-249,
2002
- Suzuki M, Zheng HY, Takasaka T, Sugimoto C, Kitamura T, Beutler E, Yogo
Y. Asian genotypes of JC virus in Japanese-Americans suggest familial
transmission. J Virol 76: 10074-10078, 2002
- Sugimoto C, Hasegawa M, Zheng HY, Demenev V, Sekino Y, Kojima K, Honjo
T, Kida H, Hovi T, Vesikari T, Schalken JA, Tomita K, Mitsunobu Y, Ikegaya
H, Kobayashi N, Kitamura T, Yogo Y. JC virus strains indigenous to
northeastern Siberians and Canadian Inuits are unique but evolutionally
related to those distributed throughout Europe and Mediterranean areas. J
Mol Evol 55: 322-335, 2002
- Saruwatari L, Sugimoto C, Kitamura T, Ohno N, Sakai E, Shresta P, Hoa BK,
Phi PT, An HP, Tuyet NT, Honjo T, Kobayashi N, Zheng HY, Takasaka T, Yogo Y.
Asian domains of four major genotypes of JC virus, Af2, B1-b, CY and SC.
Arch Virol 147:1-10, 2002
- Teratani T, Watanabe T, Kuwahara F, Kumagai H, Kobayashi S, Aoki Y,
Ishikawa A, Arai K, Nozawa R. Induced transcriptional expression of
calcium-binding protein S100A1 and S100A10 genes in human renal cell
carcinoma. Cancer Lett 175: 71-77, 2002
- Teratani T, Watanabe T, Yamahara K, Kumagai H, Ishikawa A, Arai K,
Nozawa R. Restricted expression of calcium-binding protein S100A5 in human
kidney. Biochem Biophys Res Commun 291: 623-627, 2002
- Goel M, Flechner SM, Ischikawa A, Induhara R, Mastroianni B, Savas K,
Modlin C, Goldfarb D, Feng J, Cook DJ, Novick AC. The effect of two
different cyclosporine formulations on the long-term progression to
chronic rejection in renal allograft recipients. Clin Transplant 16:
442-449, 2002
- Azuma T, Horie S, Tomita K, Takahashi T, Tanaka Y, Kashiwase K, Nieda M,
Takeuchi T, Ohta N, Shibata Y, Hirai H, Kitamura T. Dendritic cell
immunotherapy for patients with metastatic renal cell carcinoma: University
of Tokyo experience. Int J Urol 9: 340-346, 2002
- Takahashi T, Chiba S, Nieda M, Azuma T, Ishihara S, Shibata Y, Juji T,
Hirai H. Cutting edge: analysis of human V alpha24+CD8+ NK T cell is
activated by alpha-galactosylceramide-pulsed monocyte-derived dendritic
cells. J Immunol 168: 3140-3144, 2002
- Takahashi S, Yamada Y, Homma Y, Horie S, Hosaka Y, Kitamura T. Power
Doppler ultrasonography-directed prostate biopsy in men with elevated serum
PSA levels: An evaluation of the clinical utility and limitations. Urology
60: 248-252, 2002
- Suzuki E, Nishimatsu H, Nagata D, Satonaka H, Goto A, Omata M, Fujita T,
Nagai R, Hirata Y. Constitutive activation of proto-oncogen protein p21
induces cell cycle arrest in the G1 phase in contact-inhibited vascular
endothelial cells. Hypertens Res 25: 773-778, 2002
- Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase
K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T,
Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T,
Kurabayashi M, Nagai R. Kruppel-like zinc-finger transcription factor
KLF5/BTEB2 is a target for angiotensin II signaling and an essential
regulator of cardiovascular remodeling. Nat Med 8: 856-863, 2002
- Suzuki E, Nishimatsu H, Satonaka H, Walsh K, Goto A, Omata M, Fujita T,
Nagai R, Hirata Y. Angiotensin II induces myocyte enhancer factor 2- and
calcineurin/nuclear factor of activated T cell-dependent transcriptional
activation in vascular myocytes. Circ Res 90: 1004-1011, 2002
- Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki M, Nagata D,
Hayakawa H, Satonaka H, Sata M, Tojo A, Suzuki E, Kangawa K, Matsuo H,
Kitamura T, Nagai R. Role of endogenous adrenomedullin in the regulation of
vascular tone and ischemic renal injury: studies on transgenic/knockout mice
of adrenomedullin gene. Circ Res 90: 657-663, 2002
- Takahashi T, Tanaka Y, Nieda M, Azuma T, Chiba S, Juji T, Shibata Y, and
Hirai H. Dendritic cell vaccination for patients with chronic myelogenous
leukemia. Leuk Res 27: 795-802, 2003
- Azuma, T, Takahashi T, Kunisato A, Kitamura T, and Hirai H. Human CD4+
CD25+ regulatory T cells suppress NKT cell functions. Cancer Res 63:
4516-4520, 2003
- Takahashi S, Urano T, Tsuchiya F, Fujimura T, Kitamura T, Ouchi Y,
Muramatsu M, Inoue. EBAG9/RCAS1 expression and its prognostic significance
in prostatic cancer. Int J Cancer 106:310-315, 2003
- Aoki T, Inoue S, Imamura H, Fukushima J, Takahashi S, Urano T, Hasegawa
K, Ogushi T, Ouchi Y, Makuuchi M. EBAG9/RCAS1 expression in hepatocellular
carcinoma: Correlation with tumour dedifferentiation and proliferation. Eur
J Cancer 39:1552-1561, 2003
- Ishikawa A, Kawabe K. Beneficial effect of losartan against proteinuria
from the renal allograft. Transplant Proc 35: 289-290, 2003
- Kawabe K, Ishikawa A. First year of mass screening for prostatic cancer
in Yaizu city. Aktuel Urol 34: 242-243, 2003
- Kaneko T, Takahashi S, Takeuchi T, Goto T, Kitamura T. Castleman's
disease in the retroperitoneal space. J Urol 169:265-266, 2003
- Konno-Takahashi N, Takeuchi T, Shimizu T, Nishimatsu H, Fukuhara H,
Kamijo T, Moriyama N, Tejima S, Kitamura T. Engineered IGF-I expression
induces glandular enlargement in the murine prostate. J Endocrinol 177:
389-398, 2003
- Zheng HY, Sugimoto C, Hasegawa M, Kobayashi N, Kanayama A, Rodas A,
Mejia M, Nakamichi J, Guo J, Kitamura T, Yogo Y. Phylogenetic relationships
among JC virus strains in Japanese/Koreans and Native Americans speaking
Amerind or Na-Dene. J Mol Evol 56: 18-27, 2003
- Kasuya Y, Hosaka Y, Matsushima H, Goto T, Kitamura T, Okuyama A.
Prominent induction of cyclin B1 in G2/M renal cancer cells with
butyrolactone 1. Int J Urol, 10 : 323-331, 2003
- Nakagawa T, Kanai Y, Saito Y, Kitamura T, Kakizoe T, Hirohashi S.
Increased DNA methyltransferase 1 protein expression in human transitional
cell carcinoma of the bladder. J Urol, 170: 2463-2466, 2003
- Abe M, Sata M, Nishimatsu H, Nagata D, Suzuki E, Terauchi Y, Kadowaki T,
Minamino N, Kangawa K, Matsuo H, Hirata Y, Nagai R. Adrenomedullin augments
collateral development in response to acute ischemia. Biochem Biophys Res
Commun. 306:10-15, 2003
- Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Suzuki E, Sata M, Satonaka
H, Takeda R, Nagata D, Kakoki M, Hayakawa H, Kangawa K, Matsuo H, Kitamura
T, Nagai R. Endothelial responses of the aorta from adrenomedullin
transgenic mice and knockout mice. Hypertens Res 26 Suppl: S79-84, 2003
- Yogo Y, Sugimoto C, Zheng HY, Ikegaya H, Takasaka T, Kitamura T. JC
virus genotyping offers a new paradigm in the study of human populations.
Rev Med Virol 14: 179-191, 2004
- Zheng HY, Yasuda Y, Kato S, Kitamura T, Yogo Y. Stability of JC virus
coding sequences in a case of progressive multifocal leukoencephalopathy in
which the viral control region was rearranged markedly. Arch Pathol Lab Med
128: 275-278, 2004
- Zheng HY, Kitamura T, Takasaka T, Chen Q, Yogo Y. Unambiguous
identification of JC polyomavirus strains transmitted from parents to
children. Arch Virol 149: 261-273, 2004
- Nagata M, Kurimoto S, Takeuchi T, Ohta N, Minowada S, Kitamura T. Tiny
nodule in the testicle: Case report of a sertoli cell tumor. Int J Urol 11:
61-62, 2004
- Satonaka H, Suzuki E, Nishimatsu H, Oba S, Takeda R, Goto A, Omata M,
Fujita T, Nagai R, Hirata Y. Calcineurin promotes the expression of monocyte
chemoattractant protein-1 in vascular myocytes and mediates vascular
inflammation. Circ Res 94: 693-700, 2004
- Konno-Takahashi N, Takeuchi T, Nishimatsu H, Kamijo T, Tomita K,
Schalken JA, Tejima S, Kitamura T. Engineered FGF-2 expression induces
glandular epithelial hyperplasia in the murine prostatic dorsal lobe. Eur
Urol in press
- Takeuchi T, Konno-Takahashi N, Kasuya Y, Ogushi T, Nishimatsu H,
Kitamura T. IL-2 blocks the anti-tumor activity caused by depletion of CD25+
cells in a RENCA model. BJU Int in press
- Sata M, Nishimatsu H, Osuga JI, Tanaka K, Ishizaka N, Ishibashi S,
Hirata Y, Nagai R. Statins Augment Collateral Growth in Response to Ischemia
But They Do Not Promote Cancer and Atherosclerosis. Hypertension in press
- Enomoto Y, Enomoto K, Kitamura T, Kanda T. Keratinocyte-specific POU
transcription factor hSkn-1a represses the growth of cervical cancer cell
lines. Oncogene in press
Annual Report of the Graduate School of Medicine and The Faculty of Medicine
The University of Tokyo Reports for the Period April 2002 - March 2004
|
|