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Department of Dermatology
Professor
Kunihiko Tamaki, M.D., Ph.D.
Associate Professor
Kanako Kikuchi, M.D., Ph.D. Akihiko Asahina, M.D., Ph.D.
Lecturer
Mayumi Komine, M.D., Ph.D. Hironobu Ihn, M.D., Ph.D.
Hidehisa Saeki, M.D., Ph.D. Takahiro Watanabe, M.D., Ph.D.
Associate
Takafumi Kadono, M.D. Naoko Hattori, M.D.
Margit Nindl, M.D., Ph.D. Takashi Kakinuma, M.D.
Junichiro Shikada, M.D. Kennichi Yamane, M.D., Ph.D.
Akira Shirai, M.D. Takeo Maekawa, M.D.
Etsuko Kato, M.D.
Outline and Research, clinical, teaching activities
The Department of dermatology celebrated its 100th anniversary in 1990.
Originally it was founded as the Department of dermatology and Urology, which
also encompassed venereology. In 1946 the Department of dermatology was
separated from that of Urology. Department of Dermatology had its branch
department in Branch Hospital for about 50 years until these two departments
joined in 2001. A professor, two associate professors, four lecturers and nine
associates take part in inpatient and out-patient cares as well as research and
teaching activities. We usually have around 10 residents and 8 students of
doctoral PhD. Course. Thirty doctors who basically belong to our department are
currently out in affiliated hospitals mainly engaged in clinical works there.
Additionally there are four staff members abroad in the US and involved in
advanced research activities in cell biology and molecular biology as
postdoctoral fellow.
We have specialized out-patient clinic in which some of doctors who are in
affiliated hospitals also participate and each specialized service reflects its
own research field in a disease oriented manner.
O course these specialized groups performing their clinical and research
activities are not exclusive, and there are increasing communications in our
department as well as with other departments. Specialized out-patient clinic
include the following: atopic dermatitis, psoriasis, collagen diseases including
systemic sclerosis, SLE and dermatomyosites, skin surgery and laser surgery
including malignant melanoma, squamous cell carcinoma and basal cell carcinoma,
and infection especially fungal infection. These clinical groups are divided
into three main research groups; 1) immunology and allergology gourp, 2)
collagen disease group and 3) skin surgery group.
Immunology and allergology group engaged in atopic dermatitis and psoriasis
clinic and focuses on Landerhans cell and keratinocyte biology research
including cytokine and chemokine. Collagen group engaged in collagen disease
clinic and focuses mechanisms relating TGF-? and collagen. Skin surgery group
engaged in skin surgery and laser surgery clinic and focuses of tumor growth,
metastasis, fibrosis and dermatoscopic clinical study. Research groups are
maintained by associated professor or lecturer. These senior investigators have
ten to fifteen year experience as dermatologist and more than seven-year
experience of research in Japan as well as in USA. They have one to three
associates and students of Ph.D. course to extend their research.
In the out-patient clinic we see around 200 patients a day. Incisional and
excisional biopsies are frequently performed under local anesthesia at the
outpatient operation facilities belonging to our department Daily discussions
are made for initially consulted cases when they are rather difficult to
diagnose, by all staff members including Professor and Associate Professors.
Furthermore, retrospective clinical and histological discussions are held
regularly, which always give us invaluable lessons.
Concerning the in-patient clinic, we usually have around 40 patients in the
ward, which are usually taken care of by about ten staff members under the
supervision of the ward-chief. Surgical operations such as removal of
malignancies and skin grafting that require general anesthesia are also
performed weekly in the central surgical facilities.
We have ten dermatologists who are studying in the postgraduate course under the
guidance of staff members of our department.
In addition to series of lectures, clinical education is provided for fifth and
sixth grade medical students, which aims at giving a general introduction for
how to make dermatological approaches for diagnosis and treatment, with a stress
on learning how to observe and describe a variety of skin eruptions. Actually
the students are supposed to see the initially consulted, selected patients
every day for an entire week, as well as to participate in the in-patient
clinic.
References
- Kikuchi K, Kubo M, Hoashi T, Tamaki K: Decreased MMP-9 activity in the
serum of patients with diffuse cutaneous systemic sclerosis. Clin Exp
Dermatol 27: 310-315, 2002.
- Soma Y, Mizoguchi M, Yamane K, Yazawa N, Kubo M, Ihn H, Kikuchi K,
Tamaki K: Specific inhibition of human skin fibroblast chemotaxis to
platelet-derived growth factor A-chain homodimer by transforming growth
factor-?1. Arch Dermatol Res 293: 609-613, 2002.
- Lew W, Chang SK, Kwahck H, Tada Y, Nakamura K, Tamaki K: Serum monocyte
chemoattractant protein-1 is elevated in lepromatous leprosy patients with
high bacterial indices. Int J Lepr Other Mycobact Dis 70: 129-131, 2002.
- Zheng X, Nakamura K, Tojo M, Oyama N, Nishibu A, Satoh M, Kakinuma T,
Wakugawa M, Tamaki K, Kaneko F: TGF-beta (1)-mediated regulation of thymus
and activation-regulated chemokine (TARC/CCL17) synthesis and secretion by
HaCaT cells co-stimulated with TNF-alpha and IFN-gamma. J Dermatol Sci 30:
154-160, 2002.
- Komine M, Nishina H, Ohtsuki M, Nakagawa H, Tamaki K: Effects of vitamin
D3 analogues on the immunomodulatory function of keratinocytes and
lymphocytes. Tsambaos D, Merk H Eds: Modern Trends in Skin Pharmacology.
Athens: Parissianos Medical Publications; p. 67-74, 2002.
- Seiffert K, Hosoi J, Torii H, Ozawa H, Ding W, Campton K, Wagner JA,
Granstein RD: Catecholamines inhibit the antigen-presenting capability of
epidermal Langerhans cells. J Immunol 168: 6128-6135, 2002.
- Ihn H: The role of TGF-? signaling in the pathogenesis of fibrosis in
scleroderma. Arch Immunol Ther Exp 50: 325-331, 2002.
- Ihn H: Pathogenesis of fibrosis: role of TGF-? and CTGF. Curr Opin
Rheumatol 14: 681-685, 2002.
- Ihn H, Yamane K, Asano Y, Kubo M, Tamaki K: Interleukin-4 up-regulates
the expression of tissue inhibitor of metalloproteinase-2 in dermal
fibroblasts via the p38 mitogen-activated protein kinase-dependent pathway.
J Immunol 168: 1895-1902, 2002.
- Ihn H, Tamaki K: Mitogenic activity of dermatofibrosarcoma protuberans
is mediated via an extracellular signal related kinase dependent pathway. J
Invest Dermatol 119: 954-960, 2002.
- Ihn H, Asano Y, Kubo M, Yamane K, Jinnin M, Yazawa N, Fujimoto M, Tamaki
K: Clinical significance of serum surfactant protein D (SP-D) in patients
with polymyositis/dermatomyositis: correlation with interstitial lung
disease. Rheumatology 41: 1268-1272, 2002.
- Saeki H, Hattori N, Mitsui H, Adachi M, Imakado S, Ishibashi Y, Tamaki
K: A keratin 10 gene mutation (Arg156Cys) in a Japanese patient with bullous
congenital ichthyosiform erythroderna. J Dermatol 29: 168-171, 2002.
- Saeki H, Asano N, Tsunemi Y, Takekoshi T, Kishimoto M, Mitsui H, Tada Y,
Torii H, Komine M, Asahina A, Tamaki K: Polymorphisms of vitamin D receptor
gene in Japanese patients with psoriasis vulgaris. J Dermatol Sci 30:
167-171, 2002.
- Watanabe T, Kawamura T, Jacob SE, Aquilino EA, Orenstein JM, Black JB,
Blauvelt A: Pityriasis rosea is associated with systemic active infection
with both human herpesvirus-7 and human herpesvirus-6. J Invest Dermatol
119: 793-797, 2002.
- Wakugawa M, Nakamura K, Kakinuma T, Tamaki K: CC chemokine receptor 4 as
a possible target for therapy of atopic dermatitis. Drug News Perspect 15:
175-179, 2002.
- Kadono T, Inaoka T, Murayama N, Ushijima K, Nagano M, Nakamura S,
Watanabe C, Tamaki K, Ohtsuka R: Skin manifestations of arsenicosis in two
villages of Bangladesh. Int J Dermatol 41: 841-846, 2002.
- Kadono T, Venturi GM, Steeber DA, Tedder TF: Leukocyte rolling
velocities and migration are optimized by cooperative L-selectin and
intercellular adhesion molecule-1 functions. J Immunol 169: 4542-4550, 2002.
- Hamaguchi Y, Nishizawa Y, Yasui M, Hasegawa M, Kaburagi Y, Komura K,
Nagaoka T, Saito E, Shimada Y, Takehara K, Kadono T, Steeber DA, Tedder TF,
Sato S: Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced
lung fibrosis. Am J Pathol 161: 1607-1618, 2002.
- Kaburagi Y, Hasegawa M, Nagaoka T, Shimada Y, Hamaguchi Y, Komura K,
Saito E, Yanaba K, Takehara K, Kadono T, Steeber DA, Tedder TF, Sato S: The
cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1
and L-selectin expression. J Immunol 168: 2970-2978, 2002.
- Tu L, Poe JC, Kadono T, Venturi GM, Bullard DC, Tedder TF, Steeber DA: A
functional role for circulating mouse L-selectin in regulating
leukocyte/endothelial cell interactions in vivo. J Immunol 169: 2034-2043,
2002.
- Hattori N, Komine M, Yano S, Kaneko T, Hanakawa Y, Hashimoto K, Tamaki
K: Interferon-?, a strong suppressor of cell proliferation, induces
upregulation of keratin 6, one of the inflammatory- and
proliferation-associated keratins. J Invest Dermatol 119: 403-410, 2002.
- Fujimoto M, Poe JC, Satterthwaite AB, Wahl MI, Witte ON, Tedder TF:
Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte
signal transduction. J Immunol 168: 5465-5476, 2002.
- Kubo M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: Prevalence of
52-kDa and 60-kDa Ro/SS-A autoantibodies in Japanese patients with
polymyositis/dermatomyositis. J Am Acad Dermatol 47: 148-151, 2002.
- Kubo M, Ihn H, Yamane K, Tamaki K: Up-regulated expression of
transforming growth factor ? receptors in dermal fibroblasts of the skin
sections from patients with systemic sclerosis. J Rheumatol 29: 2558-2564,
2002.
- Kubo M, Ihn H, Kuwana M, Asano Y, Tamaki T, Yamane K, Tamaki K: Anti-U5
snRNP antibody as a possible serological marker for scleroderma-polymyositis
overlap. Rheumatology 41: 531-534, 2002.
- Nagaoka Y, Asahina A, Yano S, Tamaki K: Bilateral segmental
neurofibromatosis. Acta Derm Venereol 82: 219-220, 2002.
- Nagaoka Y, Nakamura K, Yasaka N, Watanabe T, Asahina A, Tamaki K:
Identification and characterization of the low-affinity receptor for
immunoglobulin E (FcepsilonRII/CD23) on murine Langerhans cells. J Invest
Dermatol 119: 130-136, 2002.
- Kakinuma T, Nakamura K, Wakugawa M, Mitsui H, Tada Y, Saeki H, Torii H,
Komine M, Asahina A, Tamaki K: Serum macrophage-derived chemokine (MDC)
levels are closely related with the disease activity of atopic dermatitis.
Clin Exp Immunol 127: 270-273, 2002.
- Kakinuma T, Nakamura K, Wakugawa M, Yano S, Saeki H, Torii H, Komine M,
Asahina A, Tamaki K: IL-4, but not IL-13, modulates TARC (thymus and
activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein
of 10kDa)/CXCL10 release by TNF? and IFN? in HaCaT cell line. Cytokine 20:
1-6, 2002.
- Sugaya M, Nakamura K, Watanabe T, Asahina A, Yasaka N, Koyama Y,
Kusubata M, Ushiki Y, Kimura K, Morooka A, Irie S, Yokoyama T, Inoue K,
Itohara S, Tamaki K: Expression of cellular prion-related protein by murine
Langerhans cells and keratinocytes. J Dermatol Sci 28: 126-134, 2002.
- Yano S, Nakamura K, Okochi H, Tamaki K: Analysis of the expression of
cutaneous lymphocyte-associated antigen on the peripheral blood and
cutaneous lymphocytes of alopecia areata patients. Acta Derm Venereol 82:
82-85, 2002.
- Ito Y, Arai S, van Oers NS, Aifantis I, von Boehmer H, Miyazaki T:
Positive selection by the pre-TCR yields mature CD8+ T cells. J Immunol 169:
4913-4919, 2002.
- Mitsui H, Komine M, Watanabe T, Kikuchi K, Okochi H, Tamaki K: Does
Hermansky-Pudlak syndrome predispose to systemic lupus erythematosus? Br J
Dermatol 146: 908-911, 2002.
- Yamane K, Ihn H, Kubo M, Tamaki K: Increased transcriptional activities
of transforming growth factor-? receptors in scleroderma fibroblasts.
Arthritis Rheum 46: 2421-2428, 2002.
- Jinnin M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: A case of linear
scleroderma with muscle calcification. Br J Dermatol 146: 1084-1086, 2002.
- Jinnin M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: Autoimmune
response to 52-kDa and 60-kDa Ro/SS-A antigens in mixed connective tissue
disease. Br J Dermatol 147: 827-829, 2002.
- Jinnin M, Ihn H, Yamane K, Asano Y, Yazawa N, Tamaki K: Serum levels of
tissue inhibitor of metalloproteinases in patients with mixed connective
tissue disease. Clin Exp Rheumatol 20: 539-542, 2002.
- Tsunemi Y, Hattori N, Saeki H, Adachi M, Komine M, Nakagawa H, Tamaki K:
A keratin 9 gene mutation (Asn160Ser) in a Japanese patient with
epidermolytic palmoplantar keratoderma. J Dermatol 29: 768-772, 2002.
- Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Fujita H, Asano N,
Kishimoto M, Tanida Y, Kakinuma T, Mitsui H, Tada Y, Wakugawa M, Torii H,
Komine M, Asahina A, Tamaki K: Interleukin-12 p40 gene (IL12B)
3'-untranslated region polymorphism is associated with susceptibility to
atopic dermatitis and psoriasis vulgaris. J Dermatol Sci 30: 161-166, 2002.
- Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Kakinuma T, Fujita H,
Asano N, Tanida Y, Wakugawa M, Torii H, Tamaki K: Interleukin-13 gene
polymorphism G4257A is associated with atopic dermatitis in Japanese
patients. J Dermatol Sci 30: 100-107, 2002.
- Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Fujita H, Asano N,
Tanida Y, Kakinuma T, Wakugawa M, Torii H, Tamaki K: Eotaxin gene single
nucleotide polymorphisms in the promoter and exon regions are not associated
with susceptibility to atopic dermatitis, but two of them in the promoter
region are associated with serum IgE levels in patients with atopic
dermatitis. J Dermatol Sci 29: 222-228, 2002.
- Ohtsuki M, Nakagawa H, Sugai J, Ozawa A, Ohkido M, Nakayama J, Hanada J,
Morimoto Y, Jimbow K, Horikoshi T, Kitahara H, Tamaki K, Urabe K, Hori Y:
Long-term continuous versus intermittent cyclosporin: therapy for psoriasis.
J Dermatol 30: 290-298, 2003.
- Takahashi T, Nakamura K, Chiba S, Kanda Y, Tamaki K, Hirai H: V alpha
24+ natural killer T cells are markedly decreased in atopic dermatitis
patients. Hum Immunol 64: 586-592, 2003.
- Adachi M, Gazel A, Pintucci G, Shuck A, Shifteh S, Ginsburg D, Rao LS,
Kaneko T, Freedberg IM, Tamaki K, Blumenberg M: Specificity in stress
response: epidermal keratinocytes exhibit specialized UV-responsive signal
transduction pathways. DNA Cell Biol 22: 665-677, 2003.
- Kuwana M, Sato S, Kikuchi K, Kawaguchi Y, Fujisaku A, Misaki Y,
Hatamochi A, Kondo H, Takehara K: Evaluation of functional disability using
the health assessment questionnaire in Japanese patients with systemic
sclerosis. J Rheumatol 30:1253-8,2003.
- Yasuoka H, Ihn H, Medsger TA Jr., Hirakata M, Kawakami Y, Ikeda Y,
Kuwana M: A novel peotein highly expressed in testis is overexpressed in
systemic sclerosis fibroblasts and targeted by autoantibodies. J Immunol
171: 6883-6890, 2003.
- Saeki H, Ohmatsu H, Hoashi T, Asano N, Idezuki T, Kawabata Y, Asahina A,
Kikuchi K, Tamaki K: Dermatofibrosarcoma protuberans with COL1A1 (exon 18) -
PDGFB (exon 2) fusion transcript. Br J Dermatol 148: 1028-1031, 2003.
- Saeki H, Hoashi T, Tada Y, Ashida R, Kuwano Y, Le Pavoux A, Shikada J,
Torii H, Kawabata Y, Kikuchi K, Tamada Y, Matsumoto Y, Tamaki K: Analysis of
gene mutations in three cases of dermatofibrosarcoma protuberans (DFSP):
ordinary DFSP, DFSP with fibrosarcomatous lesion (DFSP-FS) and lung
metastasis of DFSP-FS. J Dermatol Sci 33: 161-167, 2003.
- Sekiya T, Tsunemi Y, Miyamasu M, Ohta K, Morita A, Saeki H, Matsushima
K, Yoshie O, Tsuchiya N, Yamaguchi M, Yamamoto K, Tamaki K, Hirai K:
Variations in the human Th2-specific chemokine TARC gene. Immunogenetics 54:
742-745, 2003.
- Zheng X, Nakamura K, Tojo M, Akiba H, Oyama N, Nishibu A, Kaneko F,
Tsunemi Y, Kakinuma T, Saeki H, Tamaki K: Ultraviolet A irradiation inhibits
thymus and activation-regulated chemokine (TARC/CCL17) production by a human
keratinocyte HaCaT cell line. Eur J Dermatol 13: 348-353, 2003.
- Watanabe T, Sugaya M, Atkins AM, Aquilino EA, Yang A, Borris DL, Brady
J, Blauvelt A: Kaposi's sarcoma-associated herpesvirus latency-associated
nuclear antigen prolongs the life span of primary human umbilical vein
endothelial cells. J Virol 77: 6188-6196, 2003.
- Venturi GM, Tu L, Kadono T, Khan AI, Fujimoto Y, Oshel P, Bock CB,
Miller AS, Albrecht RM, Kubes P, Steeber DA, Tedder TF: Leukocyte migration
is regulated by L-selectin endoproteolytic release. Immunity 19: 713-724,
2003.
- Hattori N, Kaneko T, Tamaki K, Makimura K, Mochizuki T: A case of kerion
celsi due to Arthroderma benhamiae identified by DNA sequences of nuclear
ribosomal internal transcribed spacer 1 regions. Med Mycol 41: 249-251,
2003.
- Sato S, Hayakawa I, Hasegawa M, Fujimoto M, Takehara K: Function
blocking autoantibodies against matrix metalloproteinase-1 in patients with
systemic sclerosis. J Invest Dermatol 120: 542-547, 2003.
- Yanaba K, Hasegawa M, Hamaguchi Y, Fujimoto M, Takehara K, Sato S:
Longitudinal analysis of serum KL-6 levels in patients with systemic
sclerosis: association with the activity of pulmonary fibrosis. Clin Exp
Rheumatol 21: 429-436, 2003.
- Hasegawa M, Sato S, Nagaoka T, Fujimoto M, Takehara K: Serum levels of
tumor necrosis factor and interleukin-13 are elevated in patients with
localized scleroderma. Dermatology 207: 141-147, 2003.
- Furuse S, Fujii H, Kaburagi Y, Fujimoto M, Hasegawa M, Takehara K, Sato
S: Serum concentrations of the CXC chemokines interleukin 8 and
growth-regulated oncogene-alpha are elevated in patients with systemic
sclerosis. J Rheumatol 30: 1524-1528, 2003.
- Sato S, Fujimoto M, Hasegawa M, Takehara K: Antiphospholipid antibody in
localised scleroderma. Ann Rheum Dis 62: 771-774, 2003.
- Kubo M, Czuwara-Ladykowska J, Moussa O, Markiewicz M, Smith E, Silver RM,
Jablonska S, Blaszczyk M, Watson DK, Trojanowska M: Persistent
down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic
scleroderma skin. Am J Pathol 163: 571-581, 2003.
- Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, Tada Y,
Wakugawa M, Watanabe T, Torii H, Komine M, Asahina A, Nakamura K, Tamaki K:
Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in
patients with atopic dermatitis and psoriasis vulgaris. J Allergy Clin
Immunol 111: 592-597, 2003.
- Kakinuma T, Wakugawa M, Nakamura K, Hino H, Matsushima K, Tamaki K: High
level of thymus and activation-regulated chemokine in blister fluid and sera
of pat ients with bullous pemphigoid. Br J Dermatol 148: 203-10, 2003.
- Kakinuma T, Sugaya M, Nakamura K, Kaneko F, Wakugawa M, Matsushima K,
Tamaki K: Thymus and activation-regulated chemokine (TARC/CCL17) in mycosis
fungoides: serum TARC levels reflect the disease activity of mycosis
fungoides. J Am Acad Dermatol 48: 23-30, 2003.
- Zheng X, Nakamura K, Furukawa H, Nishibu A, Takahashi M, Tojo M, Kaneko
F, Kakinuma T, Tamaki K: Demonstration of TARC and CCR4 mRNA expression and
distribution using in situ RT-PCR in the lesional skin of atopic dermatitis.
J Dermatol 30: 26-32, 2003.
- Yazawa N, Fujimoto M, Sato S, Miyake K, Asano N, Nagai Y, Takeuchi O,
Takeda K, Okochi H, Akira S, Tedder TF, Tamaki K: CD19 regulates innate
immunity by the toll-like receptor RP105 signaling in B lymphocytes. Blood
102:1374-1380, 2003.
- Nagaoka Y, Okochi H, Tamaki K: Leukocytopenia after administration of
itraconazole. Mycoses 46: 240-241, 2003.
- Sugaya M, Nakamura K, Mitsui H, Takekoshi T, Saeki H, Tamaki K: Human
keratinocytes express fractalkine / CX3CL1. J Dermatol Sci 31: 179-187,
2003.
- Kawamura T, Gulden FO, Sugaya M, McNamara DT, Borris DL, Lederman
MM,Orenstein JM, Zimmerman PA, Blauvelt: R5 HIV productively infects
Langerhans cells, and infection levels are regulated by compound CCR5
polymorphisms. Proc Natl Acad Sci USA 100: 8401-8406, 2003.
- Tada Y, Asahina A, Fujita H, Sugaya M, Tamaki K: Langerhans cells do not
produce interferon-gamma. J Invest Dermatol 120: 891-892, 2003.
- Yano S, Komine M, Fujimoto M, Okochi H, Tamaki K: Interleukin 15 induces
the signals of epidermal proliferation through ERK and PI 3-kinase in a
human epidermal keratinocyte cell line, HaCaT. Biochem Biophys Res Commun
301: 841-847, 2003.
- Mitsui H, Komine M, Shirai A, Kanda N, Asahina A, Okochi H, Hitomi S,
Kimura S, Tamaki K: Chronic active EB virus infection complicated with IgG3
subclass deficiency: an adult case treated with intravenous immunoglobulin
and IFN-alpha. Acta Derm Venereol 83: 31-35, 2003.
- Wakimoto K, Chiba H, Michibata H, Seishima M, Kawasaki S, Okubo K,
Mitsui H, Torii H, Imai Y: A novel diacylglycerol acyltransferase (DGAT2) is
decreased in human psoriatic skin and increased in diabetic mice. Biochem
Biophys Res Commun 310: 296-302, 2003.
- Yamane K, Ihn H, Tamaki K: Epidermal growth factor up-regulates
expression of transforming growth factor-??receptor type II in human dermal
fibroblasts by phosphoinositide 3-kinase/ Akt signaling pathway: Resistance
to epidermal growth factor stimulation in scleroderma fibroblasts. Arthritis
Rheum 48: 1652-1666, 2003.
- Yamane K, Ihn H, Asano Y, Jinnin M, Tamaki K: Antagonistic effects of
TNF-? on TGF-? signaling through downergulation of TGF? receptor type II in
human dermal fibroblasts. J Immunol 171: 3855-3862, 2003.
- Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K: The prevalence and clinical
significance of anti-U1RNA antibodies in patients with systemic sclerosis. J
Invest Dermatol 120: 204-210, 2003.
- Jinnin M, Ihn H, Yazawa N, Asano Y, Yamane K, Tamaki K: Circulating
soluble CD40 ligand in patients with eosinophilic faciitis. Ann Rheum Dis
62: 190-191, 2003.
- Jinnin M, Ihn H, Yamane K, Asano Y, Yazawa N, Tamaki K: Plasma plasmin-?2
plasmin inhibitor complex levels are increased in systemic sclerosis with
pulmonary hypertension. Rheumatology 42: 240-243, 2003.
- Jinnin M, Ihn H, Yamane K, Asano Y, Yazawa N, Tamaki K: Clinical
features of patients with systemic sclerosis accompanied by rheumatoid
arthritis. Clin Exp Rheumatol 21: 91-94, 2003.
- Jinnin M, Ihn H, Yazawa N, Asano Y, Yamane K, Tamaki K: Elevated
circulating soluble CD40 ligand in patients with mixed connective tissue
disease. Clin Rheumatol 22: 37-39, 2003.
- Jinnin M Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: Effect of D-penicillamine
on pulmonary fibrosis in patients with systemic sclerosis. Ann Rheum Dis 62:
1019-1020, 2003.
- Jinnin M, Ihn H, Yazawa N, Asano Y, Yamane K, Tamaki K: Elevated serum
levels of manganese superoxide dismutase in patients with eosinophilic
fasciitis. Clin Rheumatol 22: 505, 2003.
- Tsunemi Y, Matsushita T, Takahashi T, Tamaki T: Childhood capillary
hemangioma presenting as infantile perianal protrusion. Dermatology 207:
408-409, 2003.
- Tsunemi Y, Nishibu A, Saeki H, Oyama N, Nakamura K, Kishimoto M, Mitsui
H, Tada Y, Torii H, Komine M, Asahina A, Kaneko F, Tamaki K: Lack of
association between the promoter polymorphisms at positions -308 and -238 of
the tumor necrosis factor alpha gene and psoriasis vulgaris in Japanese
patients. Dermatology 207: 371-374, 2003.
- Tsunemi Y, Sekiya T, Saeki H, Hirai K, Ohta K, Nakamura K, Kakinuma T,
Fujita H, Asano N, Wakugawa M, Torii H, Tamaki K: Lack of association of
CCR3 single nucleotide polymorphism with atopic dermatitis in Japanese
population. J Dermatol Sci 33: 130-133, 2003.
- Tsunemi Y, Idezuki T, Nakamura K, Tamaki K: Dermal endothelial cells
express eotaxin in hypereosinophilic syndrome. J Am Acad Dermatol 49:
918-921, 2003.
- Tsunemi Y, Ihn H, Shimada Y, Takehara K, Manabe M, Tamaki K:
Rosai-Dorfan disease presenting as large pigmented indurated plaques. Acta
Derm Venereol 83: 57-58, 2003.
- Tsunemi Y, Ihn H, Idezuki T, Okochi H, Tamaki K: Psoriasis guttata in
association with hepatocellular carcinoma. Acta Derm Venereol 83: 70-71,
2003.
- Tsunemi T, Ihn H, Nakamura K, Tamaki K: Post-transplantation chronic
graft-versus-host disease with overlapping features similar to those of
various collagen diseases. Int J Dermatol 42: 292-294, 2003.
- Tsunemi Y, Ihn H, Hattori N, Saeki H, Tamaki K: Multiple eruptive
dermatofibromas with CD34+ cells in a patient with hyperglyceridemia.
Dermatology 207: 319-321, 2003.
- Tsunemi Y, Ihn H, Saeki H, Tamaki K: Cholinergic urticaria successfully
treated with scopolamine butylbromide. Int J Dermatol 42: 850, 2003.
- Tsunemi Y, Ihn H, Saeki H, Tamaki K: Epithelioid granulomas in
post-transplantation chronic graft-versus-host disease. Br J Dermatol 149:
898-899, 2003.
- Tsunemi Y, Takahashi T, Tamaki T: Penicillium marneffei infection
diagnosed by polymerase chain reaction from the skin specimen. J Am Acad
Dermatol 49: 344-346, 2003.
- Tsunemi Y, Saeki H, Kishimoto M, Mitsui H, Tada Y, Torii H, Komine M,
Asahina A, Tamaki K, Sekiya T: Cytotoxic T lymphocyte antigen-4 gene (CTLA4)
polymorphisms in Japanese patients with psoriasis vulgaris. J Dermatol Sci
32:163-165, 2003.
- Ohno Y, Le Pavouv A, Saeki H, Asahina A, Tamaki K: A case of
subcutaneous nodular fat necrosis with lipase-secreting acinar cell
carcinoma. Int J Dermatol 42: 384-385, 2003.
- Kagami S, Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Nakamura K,
Takekoshi T, Kishimoto M, Mitsui H, Torii H, Komine M, Asahina A, Tamaki K:
Significant elevation of serum levels of eotaxin-3/CCL26, but not of
eotaxin-2/CCL24, in patients with atopic dermatitis: serum eotaxin-3/CCL26
levels reflect the disease activity of atopic dermatitis. Clin Exp Immunol
134: 309-313, 2003.
- Xiao T, Kagami S, Saeki H, Sugaya M, Kakinuma T, Fujita H, Yano S,
Mitsui H, Torii H, Komine M, Asahina A, Nakamura K, Tamaki K: Both IL-4 and
IL-13 inhibit the TNF-??and IFN-? enhanced MDC production in a human
keratinocyte cell line, HaCaT cells. J Dermatol Sci 31: 111-117, 2003.
- Xiao T, Fujita H, Saeki H, Mitsui H, Sugaya M, Tada Y, Kakinuma T, Torii
H, Nakamura K, Asahina A, Tamaki K: Thymus and activation-regulated
chemokine (TARC) produced by mouse epidermal Langerhans cells is upregulated
by TNF-?, IL-4 and downregulated by IFN-?. Cytokine 23: 126-132, 2003.
Annual Report of the Graduate School of Medicine and The Faculty of Medicine
The University of Tokyo Reports for the Period April 2002 - March 2004
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