Department of Neurosurgery
Takaaki Kirino, MD, DMSc
Akio Morita, MD, DMSc, Nobutaka Kawahara, MD, DMSc
Tomoki Todo, MD, DMSc, Kensuke Kawai, MD, DMSc,
Yasushi Ino, MD, DMSc
Kazuhide Furuya, MD, DMSc, Minoru Tanaka,MD, DMSc,
Junichi Tanaka, MD, Shigeo Sora, MD,
Masahiro Shin, MD, DMSc, Akira Iijima,MD,
Kyosuke Kamada, MD, DMSc, Keisuke Maruyama, MD, DMSc
The Department of Neurosurgery at the University of Tokyo Hospital consists of
14 staff neurosurgeons, who participate in the three major academic activities:
patient care, research and education. The staffs include a professor/chairman,
an associate professor, two lecturer and nine associates.
Clinical ward for Neurosurgery in our university hospital was founded in 1951 as
the first Neurosurgical clinic in Japan. Dr. Keiji Sano, as the founding
professor, established the Department of Neurosurgery in 1962. Dr. Kintomo
Takakura served as the second professor from 1981 to 1992. The incumbent
professor, Dr. Takaaki Kirino, has been serving as the third professor since
General and specialized outpatient clinics are open three days a week (Monday,
Wednesday and Friday). New patient are accepted two days a week (Tuesday and
Thursday). Specialized outpatient clinics are open for patient with brain
tumors, pituitary disease, spinal disease, cerebrovascular disease, epilepsy,
and gamma knife treatment. From April 2002 through March 2004, 2562 new and
23090 follow-up patients were treated at the outpatient clinics.
The Neurosurgery Ward has 35 beds on the seventh floor of the New Hospital
Building opened in Sept. 2001. From April 2002, through March 2004, 573 surgical
procedures were performed. In addition, 182 patients were treated by the gamma
knife during the same period. Nursing staffs consists of a head nurse, 19
registered nurses, 2 assistant nurses and a clinical assistant. Clinical
conference and professor's rounds are held in the morning three times a week.
Radiation oncologists and neuropathologists join our conference. Our practice
covers a wide variety of Neurosurgical disease including malignant and benign
brain tumors, hemorrhagic and occlusive cerebrovascular disease, spinal
disorders, epilepsy, pain and movement disorders.
Our department is affiliated with 42 neurosurgical institutions in and around
the city of Tokyo including 15 university medical centers, where our residents
and students are exposed to various pathologies. Surgical case volume in all
hospitals exceeds 4000cases.
Medical students take lectures of clinical neurosurgery in their second year.
Clinical case studies and bedside teaching are scheduled in the third and fourth
years. The lecturers introduce general Neurosurgery as well as the state-of-art
Neurosurgical practice to the students. At the bedside teaching and clinical
clerkship, they are offered opportunities to learn clinical management of
Neurosurgical patients in the hands-on style, and also are exposed to practice
in various subspecialties in neurosurgery through special seminars given by
experts in the fields.
We accepted 8 residents in 2002 and 10 in 2003. These residents are trained in
the university hospital and affiliated hospitals to experience every aspects of
neurosurgical practice for five years in average. Our residency training is
finalized after the sixth year, when the finishing residents serve as senior
resident at the university hospital for 12months. Academic training is provided
through numerous intramural clinical and research conference, journal clubs
seminars as well as quarterly regional meeting of Japan Neurosurgical Society.
After the residents finish their training, or during training, they can choose
to be admitted into the Ph.D. course at the graduate school of Medicine,
University of Tokyo, to be involved in advanced basic research activities for 4
year. After complete training, our graduates stay in the department to be an
associate in our or other university hospitals or become clinical staff in our
Clinical research in these two years have mainly focused on treatment of
acoustic neurinoma techniques of skull base surgery, treatment of malignant
brain tumors, radiosurgery and epilepsy surgery. The results were presented at
domestic and international meetings including Annual Meetings of the Japan
Neurosurgical Society and Annual Meetings of American Association of
Neurological Surgeons. .
Our department has been keeping prominent basic research activities as well. The
three main fields of our current research are 1) pathogenesis of cerebral
ischemia and neuronal regeneration after ischemic brain damage, 2) molecular
biology and viral therapy of brain tumors and 3) translational research with
department of engineering including development of microsurgical robotic system,
etc. As a Neurosurgical laboratory, one of the features is in vivo experiment
using our fine microsurgical techniques on small animals. In addition, we are
rapidly expanding our research facility to take advantage of state-of-art
technique in molecular biology in all aspects of our research.
The results of our clinical and basic research were presented in a variety of
domestic and international meetings. Following in the lists of papers published
in peer reviewed journals in the years 2002 and 2003.
- Asai, A, Tanahashi, N, Qiu, JH, Saito, N, Chi, S, Kawahara, N, Tanaka,
K, Kirino, T: Selective proteasomal dysfunction in the hippocampal CA1
region after transient forebrain ischemia. J Cereb Blood Flow Metab
- Kawahara, N, Kawai, K, Toyoda, T, Nakatomi, H, Furuya, K, Kirino, T:
Cardiac arrest cerebral ischemia model in mice failed to cause delayed
neuronal death in the hippocampus. Neurosci Lett 322:91-94 (2002).
- Kirino, T: Ischemic tolerance. J Cereb Blood Flow Metab 22:1283-1296
- Maruyama, K, Shin, M, Kurita, H, Tago, M, Kirino, T: Stereotactic
radiosurgery for dural arteriovenous fistula involving the superior sagittal
sinus. Case report. J Neurosurg 97(5 Suppl):481-483 (2002).
- Mukasa, A, Ueki, K, Matsumoto, S, Tsutsumi, S, Nishikawa, R, Fujimaki,
T, Asai, A, Kirino, T, Aburatani, H: Distinction in gene expression profiles
of oligodendrogliomas with and without allelic loss of 1p. Oncogene
- Nakatomi, H, Kuriu, T, Okabe, S, Yamamoto, S, Hatano, O, Kawahara, N,
Tamura, A, Kirino, T, Nakafuku, M: Regeneration of hippocampal pyramidal
neurons after ischemic brain injury by recruitment of endogenous neural
progenitors. Cell 110:429-441 (2002).
- Saito, N, Sasaki, T, Chikui, E, Yuyama, R, Kirino, T: Anterior
transpetrosal approach for pontine cavernous angioma--case report. Neurol
Med Chir (Tokyo) 42:272-274 (2002).
- Shin, M, Ueki, K, Kurita, H, Kirino, T: Malignant transformation of a
vestibular schwannoma after gamma knife radiosurgery. Lancet 360:309-310
- Shin, M, Kawamoto, S, Kurita, H, Tago, M, Sasaki, T, Morita, A, Ueki, K,
Kirino, T: Retrospective analysis of a 10-year experience of stereotactic
radio surgery for arteriovenous malformations in children and adolescents. J
Neurosurg 97:779-784 (2002).
- Monobe H, Morita A, Murofushi T: Remarkable restrotation of speech
discrimination after removal of jugular foramen schwannoma: a case report.
Eur Arch Otolaryngol 259: 170-171, 2002
- Sekhar LN, Chanda A, Morita A.: The preservation and reconstruction of
cerebral veins and sinuses. J Clin Neurosci. 9(4):391-9, 2002
- Asano, S, Kawahara, N, Kirino, T: Intradural spinal seeding of a clival
chordoma. Acta Neurochir (Wien) 145:599-603 (2003).
- Hoya, K, Asai, A, Sasaki, T, Nagata, K, Kimura, K, Kirino, T: Expression
of myosin heavy chain isoforms by smooth muscle cells in cerebral
arteriovenous malformations. Acta Neuropathol (Berl) 105:455-461 (2003).
- Ohata, K, Saito, K, Sekhar, LN, Morita, A, Kirino, T: ["How I do it" no.
6, a case with a giant petroclival meningioma presented with progressive
ataxia: how should this case be managed?]. No Shinkei Geka 31:1125 (2003).
- Watanabe, K, Saito, N, Taniguchi, M, Kirino, T, Sasaki, T: Analysis of
taste disturbance before and after surgery in patients with vestibular
schwannoma. J Neurosurg 99:999-1003 (2003).
- Furuya, K, Kawahara, N, Morita, A, Momose, T, Aoki, S, Kirino, T: Focal
hyperperfusion after superficial temporal artery-middle cerebral artery
anastomosis in a patient with moyamoya disease. Case report. J Neurosurg
- Furuya, K, Kawahara, N, Kawai, K, Toyoda, T, Maeda, K, Kirino, T:
Proximal occlusion of the middle cerebral artery in C57Black6 mice:
relationship of patency of the posterior communicating artery, infarct
evolution, and animal survival. J Neurosurg 100:97-105 (2004).
- Kawahara, N, Wang, Y, Mukasa, A, Furuya, K, Shimizu, T, Hamakubo, T,
Aburatani, H, Kodama, T, Kirino, T: Genome-wide gene expression analysis for
induced ischemic tolerance and delayed neuronal death following transient
global ischemia in rats. J Cereb Blood Flow Metab 24:212-223 (2004).
- Mukasa, A, Ueki, K, Ge, X, Ishikawa, S, Ide, T, Fujimaki, T, Nishikawa,
R, Asai, A, Kirino, T, Aburatani, H: Selective expression of a subset of
neuronal genes in oligodendroglioma with chromosome 1p loss. Brain Pathol
- Yonekura, I, Kawahara, N, Nakatomi, H, Furuya, K, Kirino, T: A model of
global cerebral ischemia in C57 BL/6 mice. J Cereb Blood Flow Metab
- Iwasaki S, Ito K, Takai Y, Morita A, Murofushi T: Chondroid chordoma at
the Jugular Foramen Causing Retrolabyrinthine lesions in both the cochlear
and vestibula branches of the eighth cranial nerve. Ann Otl Rhinol Laryngol:
- Maruyama K, Kondziolka D, Niranjan A, Flickinger JC, Lunsford LD.:
Stereotactic radiosurgery for brainstem arteriovenous malformations: factors
affecting outcome. J Neurosurg. 100(3):407-13. 2004
Annual Report of the Graduate School of Medicine and The Faculty of Medicine
The University of Tokyo Reports for the Period April 2002 - March 2004